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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.8
- 수록면
- 431 - 436 (6page)
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초록· 키워드
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In recent years, restoring anti-tumor immunity has garnered agrowing interest in cancer treatment. As potential therapeutics,immune checkpoint inhibitors have demonstrated benefits inmany clinical studies. Although various methods have beenapplied to suppress immune checkpoints to boost anti-tumorimmunity, including the use of immune checkpoint inhibitors,there are still unmet clinical needs to improve the response rateof cancer treatment. Here, we show that acetate can suppressthe expression of poliovirus receptor (PVR/CD155), a ligandfor immune checkpoint, in colon cancer cells. We demonstratedthat acetate treatment could enhance effector responses of CD8+T cells by decreasing the expression of PVR/CD155 in cancercells. We also found that acetate could reduce the expressionof PVR/CD155 by deactivating the PI3K/AKT pathway. Theseresults demonstrate that acetate-mediated expression of PVR/CD155 in cancer cells might potentiate the anti-tumor immunityin the microenvironment of cancer. Our findings indicate thatmaintaining particular acetate concentrations could be a complementarystrategy in current cancer treatment.
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