지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 29 - 37 (9page)
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The kidneys play an important role in regulating the acid-base balance. Metabolic acidosis is common in chronic kidney disease (CKD) patients and can lead to poor outcomes, such as bone demineralization, muscle mass loss, and worsening of renal function. Metabolic acidosis is usually approached with evaluating the serum bicarbonate levels but should be assessed by counting blood pH. Current guidelines recommend oral bicarbonate supplementation to maintain the serum bicarbonate levels within the normal range. However, a slow decline in the glomerular filtration rate might occur, even though the serum bicarbonate levels were in the normal range. Because the serum bicarbonate levels decrease when metabolic acidosis advances, other biomarkers are necessary to indicate acid retention for early diagnosis of metabolic acidosis. For this, urine citrate and ammonium excretion may be used to follow the course of CKD patients. Metabolic acidosis can be treated with an increased fruit and vegetable intake and oral alkali supplementation.
Previous studies have suggested that administration of oral sodium bicarbonate may preserve kidney function without significant increases in blood pressure and body weight. Veverimer, a non-absorbed, counterion-free, polymeric drug, is emerging to treat metabolic acidosis, but further researches are awaited. Further studies are also needed to clarify the target therapeutic range of serum bicarbonate and the drugs used for metabolic acidosis.
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참고문헌 (49)
참고문헌 신청
Karim Z / 2002 / Renal handling of NH4+ in relation to the control of acid-base balance by the kidney / J Nephrol 15(Suppl 5):S128~S134
Kraut JA / 2016 / Metabolic Acidosis of CKD : An Update / Am J Kidney Dis 67:307~317
Batlle D / 2017 / Metabolic Acidosis or Respiratory Alkalosis? Evaluation of a Low Plasma Bicarbonate Using the Urine Anion Gap / Am J Kidney Dis 70:440~444
Kim HJ / 2019 / Metabolic acidosis is associated with pulse wave velocity in chronic kidney disease : Results from the KNOW-CKD Study / Sci Rep 9:16139
Kraut JA / 2005 / Metabolic acidosis of CKD : diagnosis, clinical characteristics, and treatment / Am J Kidney Dis 45:978~993
Kraut JA / 2016 / Metabolic Acidosis of CKD : An Update / Am J Kidney Dis 67:307~317
Batlle D / 2017 / Metabolic Acidosis or Respiratory Alkalosis? Evaluation of a Low Plasma Bicarbonate Using the Urine Anion Gap / Am J Kidney Dis 70:440~444
Kim HJ / 2019 / Metabolic acidosis is associated with pulse wave velocity in chronic kidney disease : Results from the KNOW-CKD Study / Sci Rep 9:16139
Kraut JA / 2005 / Metabolic acidosis of CKD : diagnosis, clinical characteristics, and treatment / Am J Kidney Dis 45:978~993
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