지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 763 - 770 (8page)
- DOI
- 10.5009/gnl20212
이용수
초록· 키워드
오류제보하기
Background/Aims: We evaluated whether anti-Saccharomyces cerevisiae antibody (ASCA) titers are associated with diagnostic findings, disease activity, Paris classification phenotypes, and persistence after infliximab (IFX) treatment in children with Crohn’s disease (CD). We also investigated the role of ASCA as a predictor of mucosal healing (MH) and clinical remission (CR).
Methods: This study included 61 CD patients aged 19 years or younger who were diagnosed and treated between September 2010 and January 2019 and followed for at least 1 year. ASCA was regularly measured at the diagnosis of CD and at least 1 year after IFX therapy.
Results: The average follow-up period was 3.8±3.4 years (range, 1.0 to 7.2 years). Regression analysis showed that the ASCA titer was the only factor associated with Simple Endoscopic Score for Crohn's Disease (SES-CD) or CR among all the parameters. In patients who had achieved MH (SES-CD=0), ASCA immunoglobulin G (IgG) was not associated with MH, but in patients without MH, ASCA IgG was associated with SES-CD (p=0.005) and CR (p<0.001). The cutoff value of ASCA IgG in patients with CR was 21.8 units. However, there was no difference in the relapse rate between the ASCA IgG-positive and -negative groups during the follow-up period.
Conclusions: In patients who have not achieved MH, ASCA IgG is closely related to mucosal damage and CR. Unlike Western studies, ASCA IgG may be more helpful in predicting prognosis than immunoglobulin A in Korean patients, but it is not an appropriate indicator to predict the relapse of CD.
목차
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참고문헌 (29)
참고문헌 신청
홍석진 / 2018 / Characteristics and Incidence Trends for Pediatric Inflammatory Bowel Disease in Daegu-Kyungpook Province in Korea: a Multi-Center Study / Journal of Korean Medical Science 33(18):1~8
Benchimol EI / 2017 / Trends in epidemiology of pediatric inflammatory bowel disease in Canada : distributed network analysis of multiple population-based provincial health administrative databases / Am J Gastroenterol 112:1120~1134
El-Matary W / 2014 / Inflammatory bowel disease in children of Manitoba : 30 years’ experience of a tertiary center / J Pediatr Gastroenterol Nutr 59:763~766
이강문 / 2014 / Crohn’s disease in Korea: past, present, and future / The Korean Journal of Internal Medicine 29(5):558~570
Zhou G / 2016 / ASCA, ANCA, ALCA and many more: are they useful in the diagnosis of inflammatory bowel disease? / Dig Dis 34:90~97
Benchimol EI / 2017 / Trends in epidemiology of pediatric inflammatory bowel disease in Canada : distributed network analysis of multiple population-based provincial health administrative databases / Am J Gastroenterol 112:1120~1134
El-Matary W / 2014 / Inflammatory bowel disease in children of Manitoba : 30 years’ experience of a tertiary center / J Pediatr Gastroenterol Nutr 59:763~766
이강문 / 2014 / Crohn’s disease in Korea: past, present, and future / The Korean Journal of Internal Medicine 29(5):558~570
Zhou G / 2016 / ASCA, ANCA, ALCA and many more: are they useful in the diagnosis of inflammatory bowel disease? / Dig Dis 34:90~97
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