Type 2 Diabetes Mellitus Increases Peritonsillar Abscess Susceptibility: Real-World Evidence

Ching-Lung Wu; Ming-Shao Tsai; Ta-Jen Lee; Yun-Ting Wang; Chia-Yen Liu; Yao-Hsu Yang; Yao-Te Tsai; Cheng-Ming Hsu; Ching-Yuan Wu; Pey-Jium Chang; Geng-He Chang

doi:https://doi.org/10.21053/ceo.2020.02257

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자료유형: 학술저널

저자정보: Ching-Lung Wu (Chang Gung Memorial Hospital Taoyuan Taiwan) Ming-Shao Tsai (College of Medicine Chang Gung University Taoyuan Taiwan) Ta-Jen Lee (Chang Gung Memorial Hospital) Yun-Ting Wang (Chang Gung Memorial Hospital Chiayi) Chia-Yen Liu (Chang Gung Memorial Hospital Chiayi) Yao-Hsu Yang (Chang Gung Memorial Hospital) Yao-Te Tsai (Chang Gung Memorial Hospital Chiayi) Cheng-Ming Hsu (Chang Gung Memorial Hospital Chiayi) Ching-Yuan Wu (Chang Gung Memorial Hospital Chiayi) Pey-Jium Chang (Chang Gung Memorial Hospital) Geng-He Chang (Chang Gung Memorial Hospital)

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제14권 제3호

발행연도: 2021.8

수록면: 347 - 354 (8page)

DOI: https://doi.org/10.21053/ceo.2020.02257

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Objectives. Type 2 diabetes mellitus (T2DM) is a risk factor for deep neck infection (DNI) and leads to complications and poor outcomes. Our study aimed to investigate the risk, prognosis, and complications of peritonsillar abscess (PTA) in patients with T2DM. Methods. We extracted data of patients newly diagnosed as having T2DM between January 2000 and December 2011 from Taiwan’s National Health Insurance Research Database. These patients were matched with patients without T2DM, and PTA incidence was compared between both cohorts. Results. In total, 67,852 patients with and 135,704 patients without T2DM were enrolled. PTA incidence was significantly higher in patients with T2DM (incidence rate ratio, 1.91; P<0.001); moreover, PTA incidence was higher at 1 to 5 years after T2DM diagnosis than at <1 and >5 years after T2DM diagnosis. Cox regression analysis showed that patients with T2DM had an approximately 2-fold higher PTA risk (adjusted hazard ratio [aHR]: 1.89, P<0.001). Patients with a higher adapted Diabetes Complications Severity Index (aDCSI) had higher PTA risk than those with a lower aDCSI (aHRs: 2.17 for aDCSI ≥1, P=0.006 and 1.81 for aDCSI=0, P=0.002). T2DM patients with a high aDCSI (≥1) had a nonsignificantly longer hospitalization duration and a higher rate of DNI complications than did those with a low aDCSI (=0). Conclusion. In patients with T2DM, PTA incidence was relatively high, and it increased with T2DM severity. Moreover, T2DM patients should be particularly careful about PTA within 1 to 5 years after the diagnosis, and physicians should keep in mind that the prognosis of PTA was correlated with T2DM severity.

#Type 2 Diabetes Mellitus #Hyperglycemia #Peritonsillar Abscess #Quinsy #Diabetes Complications Severity Index

참고문헌 (18)

참고문헌 신청

Klug TE / 2016 / Peritonsillar abscess: complication of acute tonsillitis or Weber’s glands infection? / Otolaryngol Head Neck Surg 155(2):199~207

Galioto NJ / 2017 / Peritonsillar abscess / Am Fam Physician 95(8):501~506

Powell J / 2012 / An evidence-based review of peritonsillar abscess / Clin Otolaryngol 37(2):136~145

Chang GH / 2020 / Real-world evidence for increased deep neck infection risk in patients with rheumatoid arthritis / Laryngoscope 130(6):1402~1407

Ridder GJ / 2005 / Spectrum and management of deep neck space infections: an 8-year experience of 234 cases / Otolaryngol Head Neck Surg 133(5):709~714

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