지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제14권 제3호
- 발행연도
- 2021.8
- 수록면
- 328 - 337 (10page)
- DOI
- https://doi.org/10.21053/ceo.2020.01627
이용수
초록· 키워드
오류제보하기
Objectives. A polydioxanone (PDO) stent was developed to treat tracheomalacia in pediatric patients. However, its safety and efficacy need to be verified in animal studies before clinical trials in patients can be conducted. This study evaluated the safety and efficacy of a PDO stent in normal and tracheomalacia-model rabbits.
Methods. In total, 29 New Zealand white rabbits were used: 13 for evaluating the biocompatibility of the PDO stent in normal rabbits and 16 for the creation of a tracheomalacia model. The tracheomalacia model was successfully established in 12 rabbits, and PDO stents were placed in eight of those rabbits.
Results. The PDO stent was successfully positioned in the trachea of the normal rabbits using an endoscopic approach, and its degradation was observed 10 weeks later. The stent fragments did not induce distal airway obstruction or damage, and the mucosal changes that occurred after stent placement were reversed after degradation. The same procedure was performed on the tracheomalacia-model rabbits. The survival duration of the tracheomalacia rabbits with and without stents was 49.0±6.8 and 1.0±0.8 days, respectively. Thus, the PDO stent yielded a significant survival gain (P=0.001). In the tracheomalacia rabbits, stent degradation and granulation tissue were observed 7 weeks after placement, leading to airway collapse and death.
Conclusion. We successfully developed a PDO stent and an endoscopic guide placement system. The degradation time of the stent was around 10 weeks in normal rabbits, and its degradation was accelerated in the tracheomalacia model. The mucosal changes associated with PDO stent placement were reversible. Placement of the PDO stent prolonged survival in tracheomalacia-model rabbits.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Carden KA / 2005 / Tracheomalacia and tracheobronchomalacia in children and adults: an in-depth review / Chest 127(3):984~1005
Boogaard R / 2005 / Tracheomalacia and bronchomalacia in children: incidence and patient characteristics / Chest 128(5):3391~3397
McNamara VM / 2004 / Tracheomalacia / Paediatr Respir Rev 5(2):147~154
Saito Y / 2005 / Airway stenting / Surg Today 35(4):265~270
Zakaluzny SA / 2003 / Complications of tracheobronchial airway stents / Otolaryngol Head Neck Surg 128(4):478~488
Boogaard R / 2005 / Tracheomalacia and bronchomalacia in children: incidence and patient characteristics / Chest 128(5):3391~3397
McNamara VM / 2004 / Tracheomalacia / Paediatr Respir Rev 5(2):147~154
Saito Y / 2005 / Airway stenting / Surg Today 35(4):265~270
Zakaluzny SA / 2003 / Complications of tracheobronchial airway stents / Otolaryngol Head Neck Surg 128(4):478~488
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