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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제19권 제3호
- 발행연도
- 2021.8
- 수록면
- 449 - 458 (10page)
- DOI
- 10.9758/cpn.2021.19.3.449
이용수
초록· 키워드
오류제보하기
Objective: Regarding the neuroinflammatory theory of major depressive disorder (MDD), little is known about the effect of pro-inflammatory cytokines on white matter (WM) changes in MDD. We aimed to investigate the relationship between pro-inflammatory cytokines and WM alterations in patients with MDD.
Methods: Twenty-two patients with MDD and 22 healthy controls (HC) were evaluated for brain imaging and pro-inflammatory cytokines including interleukin (IL)-1?, IL-6, IL-8, interferon-? and tumor necrosis factor (TNF)-?. Tract-based spatial statistics and FreeSurfer were used for brain image analysis.
Results: The levels of TNF-? and IL-8 were significantly higher in the MDD group than in HC. Compared to HC, lower fractional anisotropy (FA), and higher median diffusivity (MD) and radial diffusivity (RD) values were found in the MDD group for several WM regions. Voxel-wise correlation analysis showed that the level of TNF-? was negatively correlated with FA, and positively correlated with MD and RD in the left body and genu of the corpus callosum, left anterior corona radiata, and left superior corona radiata.
Conclusion: Our findings suggest that TNF-? may play an important role in the WM alterations in depression, possibly through demyelination.
목차
등록된 정보가 없습니다.
참고문헌 (6)
참고문헌 신청
Hirschfeld RM / 2000 / History and evolution of the monoamine hypothesis of depression / J Clin Psychiatry 61(Suppl 6):4~6
Jurewicz A / 2005 / Tumour necrosis factor-induced death of adult human oligodendrocytes is mediated by apoptosis inducing factor / Brain 128(Pt 11):2675~2688
Sheehan DV / 1998 / The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 / J Clin Psychiatry 59(Suppl 20):22~33
Hoyoung Sohn / 2018 / Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression / PSYCHIATRY INVESTIGATION 15(6):593~601
이중서 / 2005 / 한국판 Hamilton 우울증 평가 척도의 신뢰도, 타당도 연구 / 신경정신의학 44(4):456~465
Jurewicz A / 2005 / Tumour necrosis factor-induced death of adult human oligodendrocytes is mediated by apoptosis inducing factor / Brain 128(Pt 11):2675~2688
Sheehan DV / 1998 / The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 / J Clin Psychiatry 59(Suppl 20):22~33
Hoyoung Sohn / 2018 / Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression / PSYCHIATRY INVESTIGATION 15(6):593~601
이중서 / 2005 / 한국판 Hamilton 우울증 평가 척도의 신뢰도, 타당도 연구 / 신경정신의학 44(4):456~465
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