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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한비만학회 Journal of Obesity & Metabolic Syndrome Journal of Obesity & Metabolic Syndrome Vol.30 No.3
- 발행연도
- 2021.9
- 수록면
- 233 - 247 (15page)
- DOI
- https://doi.org/10.7570/jomes21053
이용수
초록· 키워드
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Type 2 diabetes (T2D) is a multifaceted metabolic disorder associated with distinctive pathophysiological disturbances. One of the pathophysiological risk factors observed in T2D is dysregulation of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Both hormones stimulate insulin secretion by acting postprandially on pancreatic β-cell receptors. Oral glucose administration stimulates increased insulin secretion in comparison with isoglycemic intravenous glucose administration, a phenomenon known as the incretin effect. While the evidence for incretin defects in individuals with T2D is growing, the etiology behind this attenuated incretin effect in T2D is not clearly understood. Given their central role in T2D pathophysiology, incretins are promising targets for T2D therapeutics. The present review synthesizes the recent attempts to explain the biological importance of incretin hormones and explore potential pharmacological approaches that target the incretins.
목차
등록된 정보가 없습니다.
참고문헌 (90)
참고문헌 신청
Saeedi P / 2019 / Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition / Diabetes Res Clin Pract 157:107843
Zheng Y / 2018 / Global aetiology and epidemiology of type 2 diabetes mellitus and its complications / Nat Rev Endocrinol 14:88~98
Writing Group for the SEARCH for Diabetes in Youth Study Group / 2007 / Incidence of diabetes in youth in the United States / JAMA 297:2716~2724
Mayer-Davis EJ / 2017 / Incidence trends of type 1 and type 2 diabetes among youths, 2002-2012 / N Engl J Med 376:1419~1429
Defronzo RA / 2009 / Banting lecture : from the triumvirate to the ominous octet : a new paradigm for the treatment of type 2diabetes mellitus / Diabetes 58:773~795
Zheng Y / 2018 / Global aetiology and epidemiology of type 2 diabetes mellitus and its complications / Nat Rev Endocrinol 14:88~98
Writing Group for the SEARCH for Diabetes in Youth Study Group / 2007 / Incidence of diabetes in youth in the United States / JAMA 297:2716~2724
Mayer-Davis EJ / 2017 / Incidence trends of type 1 and type 2 diabetes among youths, 2002-2012 / N Engl J Med 376:1419~1429
Defronzo RA / 2009 / Banting lecture : from the triumvirate to the ominous octet : a new paradigm for the treatment of type 2diabetes mellitus / Diabetes 58:773~795
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