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자료유형
학술저널
저자정보
Chi-Hang Yee (Department of Surgery The Chinese University of Hong Kong) Jeremy Yuen-Chun Teoh (Department of Surgery The Chinese University of Hong Kong) Pui-Tak Lai (Department of Surgery The Chinese University of Hong Kong) Vivian Yee-Fong Leung (Department of Imaging and Interventional Radiology Prince of Wales Hospital) Winnie Chiu-Wing Chu (The Chinese University of Hong Kong Hong Kong SAR) Wai-man Lee (Department of Surgery The Chinese University of Hong Kong) Yuk-Him Tam (Department of Surgery The Chinese University of Hong Kong) Chi-Fai Ng (Department of Surgery The Chinese University of Hong Kong)
저널정보
대한배뇨장애요실금학회 International Neurourology Journal International Neurourology Journal 제21권 제2호
발행연도
2017.6
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128 - 132 (5page)

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Purpose: The aims of this study were to investigate the prevalence of upper tract involvement in ketamine-associated uropathy, and to determine the predictors of hydronephrosis in patients with a history of ketamine abuse. Methods: This was a cross-sectional study of a prospective cohort of patients with ketamine-associated uropathy. Data including demographics, pattern of ketamine abuse, pelvic pain and urgency or frequency (PUF) symptom score, uroflowmetry (UFM) parameters, serum renal function, and liver function tests were collected. Upon consultation, ultrasonography was performed to assess the function of the urinary system. Results: From December 2011 to October 2015, we treated 572 patients with ketamine-associated uropathy. Of these patients, 207 (36.2%) had managed to achieve abstinence at the time of their first consultation. Ninety-six patients (16.8%) in the cohort were found to have hydronephrosis on ultrasonography. Univariate analysis identified age, duration of ketamine abuse, PUF symptom score, voided volume on UFM, serum creatinine levels >100 μmol/L, and an abnormal serum liver enzyme profile as factors associated with hydronephrosis. Logistic regression revealed the following parameters to be statistically related to hydronephrosis: age (adjusted odds ratio [OR], 1.090; 95% confidence interval [CI], 1.020?1.166; P=0.012), functional bladder capacity (adjusted OR, 0.997; 95% CI, 0.995?0.999; P=0.029), serum creatinine >100 μmol/L (adjusted OR, 3.107; 95% CI, 1.238?7.794; P=0.016, and an abnormal serum liver enzyme profile (adjusted OR, 1.967; 95% CI, 1.213?3.187; P=0.006). Conclusions: Ketamine-associated uropathy can involve the upper urinary tract. Patient demographics as well as investigations of UFM, renal function tests, and liver function tests may allow us to identify at-risk patients.

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