지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 520 - 528 (9page)
- DOI
- https://doi.org/10.1186/s40824-021-00241-7
이용수
초록· 키워드
오류제보하기
Background: Superparamagnetic iron oxide (SPIO) nanoparticles have been widely used in several biomedical engineering in vivo. Although various surface modifications have been made to these non-biodegradable nanoparticles to make them more biocompatible, their toxic potential still remains a major concern. Method: In this study, we newly developed unfractionated heparin (UFH)-coated and low molecular weight heparin (LMWH)-coated SPIO nanoparticles through surface modification engineering, which was compared with commercially available dextran-coated SPIO nanoparticles. Their toxicity such as cytotoxicity, single cell gel electrophoresis (SCGE) comet assay, intracellular reactive oxygen species (ROS) content and cellular apoptosis was evaluated to hepatic HepG2 and renal HK-2 cells. Results: When UFH-, LMWH- or dextran-coated SPIO nanoparticles were applied, they did not affect the viability of HepG2 cell. However, HK-2 cells were more sensitive to dextran-coated SPIO nanoparticles than others. In genotoxicity assay using SCGE comet, DNA tail moment values in the groups treated with dextran- and LMWH coated SPIO nanoparticles significantly increased. However, UFH-coated SPIO nanoparticles was only significantly lowing DNA tail moment value. In addition, UFH-coated SPIO nanoparticles had lower cytotoxicity in HepG2 and HK-2 cells compared to dextran-coated SPIO nanoparticles, especially in terms of apoptosis and intracellular ROS production. Conclusions: Collectively, it is possible that UFH- coated SPIO nanoparticles can be used as alternative negative contrast agents.
목차
등록된 정보가 없습니다.
참고문헌 (50)
참고문헌 신청
Bulte JW / 2004 / Iron oxide MR contrast agents for molecular and cellular imaging / NMR Biomed 17:484~499
McCarthy JR / 2008 / Multifunctional magnetic nanoparticles for targeted imaging and therapy / Adv Drug Deliv Rev 60:1241~1251
Salgueirino-Maceira V / 2007 / Increasing the complexity of magnetic core/shell structured nanocomposites for biological applications / Adv Mater 19:4131~4144
Gupta AK / 2007 / Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications / Nanomedicine-Uk 2:23~39
Yang C-Y / 2009 / Labeling of human mesenchymal stem cell : Comparison between paramagnetic and superparamagnetic agents / J Appl Phys 105
McCarthy JR / 2008 / Multifunctional magnetic nanoparticles for targeted imaging and therapy / Adv Drug Deliv Rev 60:1241~1251
Salgueirino-Maceira V / 2007 / Increasing the complexity of magnetic core/shell structured nanocomposites for biological applications / Adv Mater 19:4131~4144
Gupta AK / 2007 / Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications / Nanomedicine-Uk 2:23~39
Yang C-Y / 2009 / Labeling of human mesenchymal stem cell : Comparison between paramagnetic and superparamagnetic agents / J Appl Phys 105
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Enhanced thermodynamic, pharmacokinetic and theranostic properties of polymeric micelles via hydrophobic core-clustering of superparamagnetic iron oxide nanoparticles
생체재료학회지
2022 .06
-
Finite Element Analysis for Comparison of Spinous Process Osteotomies Technique with Conventional Laminectomy as Lumbar Decompression Procedure
Yonsei Medical Journal
2015 .01
-
폐 전이 암에 대한 Lipid Coated Polymeric Nanoparticles에 관한 연구
의공학회지
2018 .01
-
Cytotoxicity and transcriptomic analysis in nanoparticle (NP)- treated cells
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Preparation of iron oxide nanoparticle combined with radioisotope for molecular imaging
대한방사성의약품학회지
2018 .01
-
In Vitro Cytotoxicity of Zinc Oxide Nanoparticles in Cultured Statens Seruminstitut Rabbit Cornea Cells
Toxicological Research
2019 .07
-
ACD-A에 아나필락시스를 보인 환자에서 UFH을 단독으로 사용한 혈장교환술 2례
대한수혈학회지
2020 .01
-
The effect of filter media on conventional filtration for nanoparticle analysis
환경독성보건학회 심포지엄 및 학술대회
2015 .06
-
효과적인 약물전달 시스템을 위한 나노입자 유도 장치
의공학회지
2017 .06
-
Bio-Inspired Green Nanoparticles: Synthesis, Mechanism, and Antibacterial Application
Toxicological Research
2016 .04
-
Nanoparticle technology and its implications in endodontics: a review
생체재료학회지
2020 .01
-
Photo-triggered Theranostic Nanoparticles in Cancer Therapy
MEDICAL LASERS
2021 .01
-
전하가 다른 PLGA 나노 입자의 생체 안정성 및 암세포에 미치는 영향
의공학회지
2018 .01
-
Biodistribution of poly clustered superparamagnetic iron oxide nanoparticle labeled mesenchymal stem cells in aminoglycoside induced ototoxic mouse model
Biomedical Engineering Letters (BMEL)
2021 .01
-
Fabrication of aerosol-based nanoparticles and their applications in biomedical fields
Journal of Pharmaceutical Investigation
2021 .01
-
Applying polyvinyl alcohol to the preparation of various nanoparticles
Journal of Pharmaceutical Investigation
2024 .05
-
Biogenic fabrication and characterization of silver nanoparticles using aqueous-ethanolic extract of lichen (Usnea longissima) and their antimicrobial activity
생체재료학회지
2018 .12
-
Assessment of nanoparticle exposure in nanosilica handling process : characteristics of nanoparticles leaking from a vacuum cleaner
대한직업환경의학회 학술대회 논문집
2017 .11
-
Bio-nano interactions: Binding proteins, polysaccharides, lipids and nucleic acids onto magnetic nanoparticles
생체재료학회지
2021 .01
-
Biological effects of zinc oxide nanoparticles on inflammation
셀메드
2016 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0