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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 502 - 508 (7page)
- DOI
- https://doi.org/10.1186/s40824-021-00237-3
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Background: Bone substrates like hydroxyapatite and tricalcium phosphate have been widely used for promoting spinal fusion and reducing the complications caused by autograft. Whitlockite has been reported to promote better bone formation in rat calvaria models compare with them, but no study investigated its effect on spinal fusion yet. Also, the higher osteoinductivity of whitlockite raised concern of ectopic ossification, which was a complication of spinal fusion surgery that should be avoided. Methods: In this study, we compared the osteoinductivity of whitlockite, hydroxyapatite, and tricalcium phosphate porous particles with SD rat spine posterolateral fusion model and investigated whether whitlockite could induce ectopic ossification with SD rat abdominal pouch model. Results: The micro-CT result from the posterolateral fusion model showed whitlockite had slightly but significantly higher percent bone volume than tricalcium phosphate, though none of the materials formed successful fusion with surrounding bone tissue. The histology results showed the bone formed on the cortical surface of the transverse process but did not form a bridge between the processes. The result from the abdominal pouch model showed whitlockite did not induce ectopic bone formation. Conclusion: Whitlockite had a potential of being a better bone substrate hydroxyapatite and tricalcium phosphate in spinal fusion with low risk of inducing ectopic ossification.
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참고문헌 (22)
참고문헌 신청
Reid JJ / 2011 / Challenges to bone formation in spinal fusion / J Biomech 44(2):213~220
Steinmann JC / 1992 / Pseudarthrosis of the spine / Clin Orthop Relat Res 284:80~90
Kim YJ / 2005 / Pseudarthrosis in primary fusions for adult idiopathic scoliosis : incidence, risk factors, and outcome analysis / Spine 30(4):468~474
Cho JH / 2017 / Efficacy of Escherichia coli-derived recombinant human bone morphogenetic protein-2 in posterolateral lumbar fusion : an open, active-controlled, randomized, multicenter trial / Spine J 17(12):1866~1874
Yuan Zhe Jin / 2018 / Mesenchymal Stem Cell Therapy for Bone Regeneration / Clinics in Orthopedic Surgery 10(3):271~278
Steinmann JC / 1992 / Pseudarthrosis of the spine / Clin Orthop Relat Res 284:80~90
Kim YJ / 2005 / Pseudarthrosis in primary fusions for adult idiopathic scoliosis : incidence, risk factors, and outcome analysis / Spine 30(4):468~474
Cho JH / 2017 / Efficacy of Escherichia coli-derived recombinant human bone morphogenetic protein-2 in posterolateral lumbar fusion : an open, active-controlled, randomized, multicenter trial / Spine J 17(12):1866~1874
Yuan Zhe Jin / 2018 / Mesenchymal Stem Cell Therapy for Bone Regeneration / Clinics in Orthopedic Surgery 10(3):271~278
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