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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 434 - 445 (12page)
- DOI
- https://doi.org/10.1186/s40824-021-00244-4
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초록· 키워드
오류제보하기
Background: Aptamer has been called “chemical antibody” which displays the specific affinity to target molecules compared to that of antibodies and possesses several therapeutic advantages over antibodies in terms of size, accessibility to synthesis, and modification. Based on the attractive properties, aptamers have been interested in many directions and now are emerged as new target-designed cancer drug. Main body: Currently, new types of aptamers have been reported and attracted many scientists’ interesting. Due to simplicity of chemical modification and ready-made molecular engineering, scientists have developed newly designed aptamers conjugated with a wide range of therapeutics, aptamer-drug conjugates; ApDCs, from chemotherapy to phototherapy, gene therapy, and vaccines. ApDCs display synergistic therapeutic effects in cancer treatment. Conclusion: In this paper, we reviewed various kinds of ApDCs, i.e., ApDC nucleotide analogs, ApDC by drug intercalation, and ApDC by using chemical linker. Current data prove these ApDCs have sufficient potential to complete clinical development soon. Advanced technology of cancer drug delivery and combination treatment of cancers enables aptamer and conjugated drug (ApDCs) efficient means for targeted cancer treatment that reduces potential toxicity and increases therapeutic efficacy.
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등록된 정보가 없습니다.
참고문헌 (65)
참고문헌 신청
Ali MH / 2019 / Updates on Aptamer Research / Int J Mol Sci 20(10):2511
Ellington AD / 1990 / In vitro selection of RNA molecules that bind specific ligands / Nature 346(6287):818~822
Tuerk C / 1990 / Systematic evolution of ligands by exponential enrichment : RNA ligands to bacteriophage T4 DNA polymerase / Science 249(4968):505~510
Ellington AD / 1992 / Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures / Nature 355(6363):850~852
Bock LC / 1992 / Selection of singlestranded DNA molecules that bind and inhibit human thrombin / Nature 355(6360):564~566
Ellington AD / 1990 / In vitro selection of RNA molecules that bind specific ligands / Nature 346(6287):818~822
Tuerk C / 1990 / Systematic evolution of ligands by exponential enrichment : RNA ligands to bacteriophage T4 DNA polymerase / Science 249(4968):505~510
Ellington AD / 1992 / Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures / Nature 355(6363):850~852
Bock LC / 1992 / Selection of singlestranded DNA molecules that bind and inhibit human thrombin / Nature 355(6360):564~566
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