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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 269 - 277 (9page)
- DOI
- https://doi.org/10.1186/s40824-021-00221-x
이용수
초록· 키워드
오류제보하기
Background: Wilson disease (WD) is a genetic disorder of copper storage, resulting in pathological accumulation of copper in the body. Because symptoms are generally related to the liver, chelating agents capable of capturing excess copper ions after targeted delivery to the liver are highly required for the treatment of WD. Methods: We developed hyaluronate-diaminohexane/black phosphorus (HA-DAH/BP) complexes for capturing copper ions accumulated in the liver for the treatment of WD. Results: HA-DAH/BP complexes showed high hepatocyte-specific targeting efficiency, selective copper capturing capacity, excellent biocompatibility, and biodegradability. HA enhanced the stability of BP nanosheets and increased copper binding capacity. In vitro cellular uptake and competitive binding tests verified targeted delivery of HA-DAH/BP complexes to liver cells via HA receptor mediated endocytosis. The cell viability test confirmed the high biocompatibility of HA-DAH/BP complexes. Conclusion: HA-DAH/BP complexes would be an efficient copper chelating agent to remove accumulated copper in the liver for the WD treatment.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Ala A / 2007 / Wilson’s disease / Lancet 369(9559):397~408
Petrasek J / 2007 / Revised King’s college score for liver transplantation in adult patients with Wilson’s disease / Liver Transpl 13(1):55~61
Roberts EA / 2008 / Diagnosis and treatment of Wilson disease : an update / Hepatology 47(6):2089~2111
Askari FK / 2003 / Treatment of Wilson’s disease with zinc. XVIII Initial treatment of the hepatic decompensation presentation with trientine and zinc / J Lab Clin Med 142(6):385~390
Santos SEE / 1996 / Successful medical treatment of severely decompensated Wilson disease / J Pediatr 128(2):285~287
Petrasek J / 2007 / Revised King’s college score for liver transplantation in adult patients with Wilson’s disease / Liver Transpl 13(1):55~61
Roberts EA / 2008 / Diagnosis and treatment of Wilson disease : an update / Hepatology 47(6):2089~2111
Askari FK / 2003 / Treatment of Wilson’s disease with zinc. XVIII Initial treatment of the hepatic decompensation presentation with trientine and zinc / J Lab Clin Med 142(6):385~390
Santos SEE / 1996 / Successful medical treatment of severely decompensated Wilson disease / J Pediatr 128(2):285~287
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