Prognostic Value of Serum Epstein?Barr Virus Antibodies and Their Correlation with TNM Classi?cation in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma

Wan-Ru Zhang; Yu-Yun Du; Chun-Yan Guo; Han-Xing Zhou; Jie-Yi Lin; Xiao-Han Meng; Hao-Yuan Mo; Dong-Hua Luo

doi:10.4143/crt.2020.1298

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저자정보: Wan-Ru Zhang (Sun Yat‐sen University Cancer Center Guangzhou China) Yu-Yun Du (Sun Yat‐sen University Cancer Center Guangzhou China) Chun-Yan Guo (Sun Yat‐sen University Cancer Center Guangzhou China) Han-Xing Zhou (Sun Yat‐sen University Cancer Center Guangzhou China) Jie-Yi Lin (Sun Yat‐sen University Cancer Center Guangzhou China) Xiao-Han Meng (Sun Yat‐sen University Cancer Center Guangzhou China) Hao-Yuan Mo (Sun Yat‐sen University Cancer Center Guangzhou China) Dong-Hua Luo (Sun Yat‐sen University Cancer Center Guangzhou China)

저널정보: 대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제53권 제4호

발행연도: 2021.10

수록면: 991 - 1,003 (13page)

DOI: 10.4143/crt.2020.1298

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Purpose This study assessed the correlation between Epstein-Barr virus (EBV) biomarkers and the eighth American Joint Committee on Cancer staging system and the prognostic values of IgG antibodies against replication and transcription activator (Rta-IgG), IgA antibodies against Epstein-Barr nuclear antigen 1, and BamH1 Z transactivator (Zta-IgA) in locoregionally advanced nasopharyngeal carcinoma (NPC) patients. Materials and Methods Serum EBV antibody levels were measured by enzyme-linked immunosorbent assay in 435 newly diagnosed stage III-IVA NPC patients administered intensity-modulated radiation therapy±chemotherapy. The primary endpoint was progression-free survival (PFS). Results Rta-IgG and Zta-IgA levels were positively correlated with the N category and clinical stage. Patients with high Rta-IgG levels (> 29.07 U/mL) showed a significantly inferior prognosis as indicated by PFS (77% vs. 89.8%, p=0.004), distant metastasis?free survival (DMFS) (88.3% vs. 95.8%, p=0.021), and local recurrence-free survival (LRFS) (91.2% vs. 98.3%, p=0.009). High Rta-IgG levels were also significantly associated with inferior PFS and LRFS in multivariable analyses. In the low-level EBV DNA group (≤ 1,500 copies/mL), patients with high Rta-IgG levels had significantly inferior PFS and DMFS (both p < 0.05). However, in the high-level EBV DNA group, Rta-IgG levels were not significantly associated with PFS, DMFS, and LRFS. In the advanced T category (T3-4) subgroup, high Rta-IgG levels were also significantly associated with inferior PFS, DMFS, and LRFS (both p < 0.05). Conclusion Rta-IgG and Zta-IgA levels were strongly correlated with the TNM classification. Rta-IgG level was a negative prognostic factor in locoregionally advanced NPC patients, especially those with advanced T category or low EBV DNA level.

#Epstein?Barr virus antibodies #Nasopharyngeal carcinoma #TNM classification #Prognosis

참고문헌 (30)

참고문헌 신청

Yu WM / 2009 / Incidence of nasopharyngeal carcinoma in Chinese immigrants, compared with Chinese in China and South East Asia : review / J Laryngol Otol 123:1067~1074

Chang ET / 2006 / The enigmatic epidemiology of nasopharyngeal carcinoma / Cancer Epidemiol Biomarkers Prev 15:1765~1777

Yi JL / 2006 / Nasopharyngeal carcinoma treated by radical radiotherapy alone : Ten-year experience of a single institution / Int J Radiat Oncol Biol Phys 65:161~168

Leung SF / 2003 / Pretherapy quantitative measurement of circulating EpsteinBarr virus DNA is predictive of posttherapy distant failure in patients with early-stage nasopharyngeal carcinoma of undifferentiated type / Cancer 98:288~291

Leung SF / 2006 / Plasma Epstein-Barr viral deoxyribonucleic acid quantitation complements tumor-node-metastasis staging prognostication in nasopharyngeal carcinoma / J Clin Oncol 24:5414~5418

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