지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 1,134 - 1,147 (14page)
- DOI
- 10.4143/crt.2020.1191
이용수
초록· 키워드
오류제보하기
Purpose Chemotherapy-related cognitive impairment (CRCI) is a controversial concept not much explored on colorectal cancer patients.
Materials and Methods We identified 11 prospective studies: eight studies on 696 colorectal cancer patients who received chemotherapy and three studies on 346 rectal cancer patients who received neoadjuvant chemoradiotherapy. Standardized mean differences (SMDs) of neuropsychological test results and the cognitive quality-of-life scale were calculated using random effect models. A meta-regression was conducted to investigate the association between mean study population age and effect sizes.
Results The association between chemotherapy and cognitive impairment was not clear in colorectal cancer patients (SMD, 0.003; 95% confidence interval, ?0.080 to 0.086). However, a meta-regression showed that older patients are more vulnerable to CRCI than younger patients (β=?0.016, p < 0.001).
Conclusion Chemotherapy has an overall positive negligible effect size on the cognitive function of colorectal patients. Age is a significant moderator of CRCI.
목차
등록된 정보가 없습니다.
참고문헌 (51)
참고문헌 신청
Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68:394~424
van Dam FS / 1998 / Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer : high-dose versus standard-dose chemotherapy / J Natl Cancer Inst 90:210~218
Anderson-Hanley C / 2003 / Neuropsychological effects of treatments for adults with cancer : a meta-analysis and review of the literature / J Int Neuropsychol Soc 9:967~982
Cruzado JA / 2014 / Longitudinal study of cognitive dysfunctions induced by adjuvant chemotherapy in colon cancer patients / Support Care Cancer 22:1815~1823
Vardy JL / 2015 / Cognitive function in patients with colorectal cancer who do and do not receive chemotherapy : a prospective, longitudinal, controlled study / J Clin Oncol 33:4085~4092
van Dam FS / 1998 / Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer : high-dose versus standard-dose chemotherapy / J Natl Cancer Inst 90:210~218
Anderson-Hanley C / 2003 / Neuropsychological effects of treatments for adults with cancer : a meta-analysis and review of the literature / J Int Neuropsychol Soc 9:967~982
Cruzado JA / 2014 / Longitudinal study of cognitive dysfunctions induced by adjuvant chemotherapy in colon cancer patients / Support Care Cancer 22:1815~1823
Vardy JL / 2015 / Cognitive function in patients with colorectal cancer who do and do not receive chemotherapy : a prospective, longitudinal, controlled study / J Clin Oncol 33:4085~4092
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