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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제4호
- 발행연도
- 2018.7
- 수록면
- 399 - 408 (10page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.4.399
이용수
초록· 키워드
오류제보하기
A lipidomic study on extensive plasma lipids in bacterial peritonitis (cecal ligation and puncture, CLP)-induced sepsis in mice was done at 24 h post-CLP. The effects of administration of lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), compounds known to have beneficial effects in CLP, on the sepsis-induced plasma lipid changes were also examined. Among the 147 plasma lipid species from 13 lipid subgroups (fatty acid [FA], LPA, LPC, lysophosphatidylethanolamine [LPE], phosphatidic acid [PA], phosphatidylcholine [PC], phosphatidylethanolamine [PE], phosphatidylinositol [PI], monoacylglyceride [MG], diacylglyceride [DG], triacylglyceride [TG], sphingomyelin [SM], and ceramide [Cer]) analyzed in this study, 40 and 70 species were increased, and decreased, respectively, in the CLP mice. Treatments with LPC and LPA affected 14 species from 7 subgroups, and 25 species from 9 subgroups, respectively. These results could contribute to finding the much needed reliable biomarkers of sepsis.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Ghosh A / 2017 / Biofluid lipidome: a source for potential diagnostic biomarkers / Clin Transl Med 6:22
Quehenberger O / 2010 / Lipidomics reveals a remarkable diversity of lipids in human plasma / J Lipid Res 51:3299~3305
Drobnik W / 2003 / Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients / J Lipid Res 44:754~761
Levels JH / 2007 / Alterations in lipoprotein homeostasis during human experimental endotoxemia and clinical sepsis / Biochim Biophys Acta 1771:1429~1438
Nogueira AC / 2008 / Changes in plasma free fatty acid levels in septic patients are associated with cardiac damage and reduction in heart rate variability / Shock 29:342~348
Quehenberger O / 2010 / Lipidomics reveals a remarkable diversity of lipids in human plasma / J Lipid Res 51:3299~3305
Drobnik W / 2003 / Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients / J Lipid Res 44:754~761
Levels JH / 2007 / Alterations in lipoprotein homeostasis during human experimental endotoxemia and clinical sepsis / Biochim Biophys Acta 1771:1429~1438
Nogueira AC / 2008 / Changes in plasma free fatty acid levels in septic patients are associated with cardiac damage and reduction in heart rate variability / Shock 29:342~348
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