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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제3호
- 발행연도
- 2018.5
- 수록면
- 291 - 300 (10page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.3.291
이용수
초록· 키워드
오류제보하기
The purpose of the present work is to establish an ultra-minimal invasive percutaneous puncture inoculation method for a VX2 orthotopic lung cancer rabbit model with fewer technical difficulties, lower mortality of rabbits, a higher success rate and a shorter operation time, to evaluate the growth, metastasis and apoptosis of tumor by CT scans, necropsy, histological examination, flow cytometry and immunohistochemistry.
The average inoculation time was 10-15 min per rabbit. The tumorbearing rate was 100%. More than 90% of the tumor-bearing rabbits showed local solitary tumor with 2-10 mm diameters after two weeks post-inoculation, and the rate of chest seeding was only 8.3% (2/24). The tumors diameters increased to 4-16 mm, and irregularly short thorns were observed 3 weeks after inoculation. Five weeks post-inoculation, the liquefaction necrosis and a cavity developed, and the size of tumor grew further. Before natural death, the CT images showed that the tumors spread to the chest. The flow cytometry and immunohistochemistry indicated that there was less apoptosis in VX2 orthotopic lung cancer rabbit model compared to chemotherapy drug treatment group. Minimal invasive percutaneous puncture inoculation is an easy, fast and accurate method to establish the VX2 orthotopic lung cancer rabbit model, an ideal in situ tumor model similar to human malignant tumor growth.
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참고문헌 (29)
참고문헌 신청
Stewart BW / 2014 / World Cancer Report 2014
Siegel RL / 2016 / Cancer statistics, 2016 / CA Cancer J Clin 66:7~30
Chen W / 2016 / Cancer statistics in China, 2015 / CA Cancer J Clin 66:115~132
Zhao L / 2011 / Solid dispersion and effervescent techniques used to prepare docetaxel liposomes for lung-targeted delivery system: in vitro and in vivo evaluation / J Drug Target 19:171~178
Razi SS / 2015 / Antitumor activity of paclitaxel is significantly enhanced by a novel proapoptotic agent in non-small cell lung cancer / J Surg Res 194:622~630
Siegel RL / 2016 / Cancer statistics, 2016 / CA Cancer J Clin 66:7~30
Chen W / 2016 / Cancer statistics in China, 2015 / CA Cancer J Clin 66:115~132
Zhao L / 2011 / Solid dispersion and effervescent techniques used to prepare docetaxel liposomes for lung-targeted delivery system: in vitro and in vivo evaluation / J Drug Target 19:171~178
Razi SS / 2015 / Antitumor activity of paclitaxel is significantly enhanced by a novel proapoptotic agent in non-small cell lung cancer / J Surg Res 194:622~630
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