지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제6호
- 발행연도
- 2017.11
- 수록면
- 687 - 694 (8page)
이용수
초록· 키워드
오류제보하기
Plumbagin, a hydroxy 1,4-naphthoquinone compound from plant metabolites, exhibits anticancer, antibacterial, and antifungal activities via modulating various signaling molecules. However, its effects on vascular functions are rarely studied except in pulmonary and coronary arteries where NADPH oxidase (NOX) inhibition was suggested as a mechanism. Here we investigate the effects of plumbagin on the contractility of skeletal artery (deep femoral artery, DFA), mesenteric artery (MA) and renal artery (RA) in rats. Although plumbagin alone had no effect on the isometric tone of DFA, 1 μM phenylephrine (PhE)-induced partial contraction was largely augmented by plumbagin (ΔTPlum, 125% of 80 mM KCl-induced contraction at 1 μM). With relatively higher concentrations (>5 μM), plumbagin induced a transient contraction followed by tonic relaxation of DFA. Similar biphasic augmentation of the PhE-induced contraction was observed in MA and RA. VAS2870 and GKT137831, specific NOX4 inhibitors, neither mimicked nor inhibited ΔTPlum in DFA. Also, pretreatment with tiron or catalase did not affect ΔTPlum of DFA. Under the inhibition of PhEcontraction with L-type Ca2+ channel blocker (nifedipine, 1 μM), plumbagin still induced tonic contraction, suggesting Ca2+-sensitization mechanism of smooth muscle.
Although ΔTPlum was consistently observed under pretreatment with Rho A-kinase inhibitor (Y27632, 1 μM), a PKC inhibitor (GF 109203X, 10 μM) largely suppressed ΔTPlum. Taken together, it is suggested that plumbagin facilitates the PKC activation in the presence of vasoactive agonists in skeletal arteries. The biphasic contractile effects on the systemic arteries should be considered in the pharmacological studies of plumbagin and 1,4-naphthoquinones.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Padhye S / 2012 / Perspectives on medicinal properties of plumbagin and its analogs / Med Res Rev 32:1131~1158
Courboulin A / 2012 / Plumbagin reverses proliferation and resistance to apoptosis in experimental PAH / Eur Respir J 40:618~629
Ding Y / 2005 / Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone / J Pharm Pharmacol 57:111~116
Ahmad M / 2010 / Roles for Nox4in the contractile response of bovine pulmonary arteries to hypoxia / Am J Physiol Heart Circ Physiol 298:H1879~H1888
Smith RM / 2015 / Role of Nox inhibitors plumbagin, ML090 and gp91ds-tat peptide on homocysteine thiolactone induced blood vessel dysfunction / Clin Exp Pharmacol Physiol 42:860~864
Courboulin A / 2012 / Plumbagin reverses proliferation and resistance to apoptosis in experimental PAH / Eur Respir J 40:618~629
Ding Y / 2005 / Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone / J Pharm Pharmacol 57:111~116
Ahmad M / 2010 / Roles for Nox4in the contractile response of bovine pulmonary arteries to hypoxia / Am J Physiol Heart Circ Physiol 298:H1879~H1888
Smith RM / 2015 / Role of Nox inhibitors plumbagin, ML090 and gp91ds-tat peptide on homocysteine thiolactone induced blood vessel dysfunction / Clin Exp Pharmacol Physiol 42:860~864
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Differential effects of saturated and unsaturated fatty acids on vascular reactivity in isolated mesenteric and femoral arteries of rats
The Korean Journal of Physiology & Pharmacology
2019 .01
-
Effects of high glucose with or without other metabolic substrates on alpha-adrenergic contractions in rat mesenteric and femoral arteries
The Korean Journal of Physiology & Pharmacology
2017 .01
-
Anomalous Origin of the Right Coronary Artery from the Pulmonary Artery
전남의대학술지
2024 .09
-
Right Gastroepiploic Artery Transposition for a Common Hepatic Artery and Proper Hepatic Artery Aneurysm Repair
Vascular Specialist International
2023 .03
-
Totally Occluded Grafted Right Internal Mammary Artery to Anomalously Originated Right Coronary Artery
전남의대학술지
2015 .01
-
Multimodality Imaging of Anomalous Left Coronary Artery from the Pulmonary Artery
Journal of Cardiovascular Imaging
2017 .01
-
Extensive Papillary Muscle Calcification in Adult Anomalous Left Coronary Artery from Pulmonary Artery
Korean Circulation Journal
2024 .01
-
Complex Variations in Branching Pattern of the Axillary Artery and Hands with the Persistent Median Artery
해부·생물인류학
2020 .12
-
Effect of different contraction methods on pelvic floor muscle contraction in middle-aged women
Physical therapy rehabilitation science
2015 .01
-
A rare type of single coronary artery with right coronary artery originating from the left circumflex artery in a child
Clinical and Experimental Pediatrics
2015 .01
-
Unusual Cause of Ischemic Heart Disease in a 34-Year Old Woman: Anomalous Left Coronary Artery From the Pulmonary Artery
Korean Circulation Journal
2023 .06
-
Assessing the short-term effects of radiotherapy on the shear modulus of the common carotid artery as a new biomarker of radiation-induced atherosclerosis
ULTRASONOGRAPHY
2022 .01
-
The effect of differences in warm-up and muscle contraction methods on muscle activity and total work during the bench press exercise in Republic of Korea: experimental research
MEDICAL LASERS
2023 .06
-
The bifunctional effect of propofol on thromboxane agonist (U46619)-induced vasoconstriction in isolated human pulmonary artery
The Korean Journal of Physiology & Pharmacology
2017 .11
-
Editorial : Importance of coronary artery dominance in children to determine coronary artery dilatation
Clinical and Experimental Pediatrics
2019 .01
-
Neutrophil- to-Lymphocyte Ratio for Risk Assessment in Coronary Artery Disease and Carotid Artery Atherosclerosis
Journal of Cardiovascular Imaging
2016 .01
-
A Functional Perspective on the Embryology and Anatomy of the Cerebral Blood Supply
대한뇌졸중학회지
2015 .01
-
Fusiform “True” Posterior Communicating Artery Aneurysm with Basilar Artery Occlusion: A Case Report
Neurointervention
2024 .03
-
Images in cardiovascular disease. The right type of single coronary artery
Journal of Cardiovascular Imaging
2024 .06
-
Spontaneous dissections of multiple visceral arteries : an extremely rare case
Annals of Surgical Treatment and Research
2017 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0