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자료유형
학술저널
저자정보
Jue Seong Lee (Korea University College of Medicine and Korea University Medical Center) Gi Beom Kim (Seoul National University Children’s Hospital) Won Jung Lee (Seoul National University College of Medicine) Seok Hyun Song (Seoul National University College of Medicine) Hyo Soon An (Seoul National University Children's Hospital) Sang Yun Lee (Seoul National University Children's Hospital) Mi Kyoung Song (Seoul National University Children’s Hospital) Hye Won Kwon (Seoul National University Children’s Hospital) Eun Jung Bae (Seoul National University Children’s Hospital)
저널정보
대한심장학회 Korean Circulation Journal Korean Circulation Journal Vol.51 No.12
발행연도
2021.12
수록면
1,017 - 1,029 (13page)
DOI
https://doi.org/10.4070/kcj.2021.0076

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Background and Objectives: While diuretics are sometimes used in atrial septal defect (ASD) treatment, their effect on ASD size reduction remains unclear. We aimed to evaluate the efficacy of diuretics in ASD size reduction in pediatric patients. Methods: We retrospectively reviewed the medical records of patients with secundum ASD (size ≥10 mm), between 2005 and 2019. Patients were divided into two groups based on the diuretic administration. Results: Of the 73 enrolled patients, 40 received diuretics. The initial age at ASD diagnosis (2.8±1.7 vs. 2.5±2.0 years, p=0.526) and follow-up duration (22.3±11.4 vs. 18.7±13.2 months, p=0.224) were not significantly different between the groups. The ASD diameter at the initial diagnosis (13.7±2.0 vs. 13.5±3.4 mm, p=0.761) and the indexed ASD diameter (25.5±5.9 vs. 26.9±10.3 mm/m2, p=0.493) were also not significantly different between two groups. The ASD diameter significantly increased in the non-diuretic group during follow-up (0.0±2.9 vs. +2.6±2.0 mm, p<0.001). The indexed ASD diameter significantly decreased in the diuretic group during follow-up (?5.7±6.5 vs. +0.2±3.9 mm/m2, p<0.001). In the linear mixed model analysis, diuretic use was associated with ASD diameter decrease (p<0.001) and indexed ASD diameter reduction (p<0.001) over time. Device closure was more frequently performed in the diuretic (75.0%) than in the non-diuretic group (39.4%). Conclusions: Patients receiving diuretics are less likely to undergo surgery. The diuretics administration may be associated with the use of smaller ASD devices for transcatheter treatment through ASD size reduction.

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