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Sex-Related Outcomes of Successful Drug-Coated Balloon Treatment in De Novo Coronary Artery Disease
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논문 기본 정보

Type
Academic journal
Author
Liu Kun (Peking University Shougang Hospital) Eun-Seok Shin (울산대학교) Eun Jung Jun (울산병원) Youngjune Bhak (울산과학기술원(UNIST)) Scot Garg (East Lancashire Hospitals NHS Trust UK) Tae-Hyun Kim (울산병원) Chang-Bae Sohn (울산병원) Byung Joo Choi (울산병원) Lin Hui (Peking University Shougang Hospital) Song Lin Yuan (동아대학교병원)
Journal
Yonsei University College of Medicine Yonsei Medical Journal Yonsei Medical Journal 제62권 제11호 KCI Accredited Journals
Published
2021.11
Pages
981 - 989 (9page)
DOI
10.3349/ymj.2021.62.11.981

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Sex-Related Outcomes of Successful Drug-Coated Balloon Treatment in De Novo Coronary Artery Disease
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Purpose: Although drug-coated balloon (DCB) treatment is known to be effective for de novo lesions, the influence of sex on angiographic and clinical outcomes remains unknown. This study aimed to investigate the angiographic and clinical impact of DCB treatment in patients with de novo coronary lesions according to sex. Materials and Methods: A total of 227 patients successfully treated with DCB were retrospectively enrolled and divided into two groups according to sex. The primary endpoint was late lumen loss (LLL) at 6-month angiography, and the secondary endpoint was target vessel failure (TVF), which included cardiac death, target vessel myocardial infarction, target lesion revascularization, and target vessel thrombosis. Results: The study enrolled 60 women (26.4%) and 167 men (73.6%). Compared to men, women had a smaller vessel size, larger DCB to reference vessel ratio, and more dissections after DCB treatment (55.0% vs. 37.1%, p=0.016). Women also had a significantly higher LLL compared to men (0.12±0.26 mm vs. 0.02±0.22 mm, p=0.012) at the 6-month follow-up angiography. During a median follow-up of 3.4 years (range 12.7?28.9 months), TVF was similar (women 6.7% vs. men 7.8%, p=0.944). In multivariable analysis, women were independently associated with a higher LLL. Conclusion: LLL was higher in women, but there was no difference in TVF between women and men. Based on multivariable analysis, the women sex was an independent predictor of higher LLL (Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion; NCT04619277).
#Drug-coated balloon #balloon angioplasty #coronary artery disease #sex difference #clinical outcome

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References (23)

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Funakoshi S / 2011 / Clinical characteristics and outcomes of Japanese women undergoing coronary revascularization therapy / Circ J 75:1358~1367 google schola Kornowski R / 2012 / A comparative analysis of major clinical outcomes with drug-eluting stents versus bare metal stents in male versus female patients / EuroIntervention 7:1051~1059 google schola Mehran R / 2010 / A risk score to predict bleeding in patients with acute coronary syndromes / J Am Coll Cardiol 55:2556~2566 google schola Rao SV / 2013 / An updated bleeding model to predict the risk of post-procedure bleeding among patients undergoing percutaneous coronary intervention : a report using an expanded bleeding definition from the National Cardiovascular Data Registry CathPCI Registry / JACC Cardiovasc Interv 6:897~904 google schola Yu J / 2016 / Sexbased differences in cessation of dual-antiplatelet therapy following percutaneous coronary intervention with stents / JACC Cardiovasc Interv 9:1461~1469 google schola

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