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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 936 - 942 (7page)
- DOI
- 10.3349/ymj.2021.62.10.936
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초록· 키워드
오류제보하기
Purpose: A critical indicator of the overall survival of patients with high-grade glioma is the successful isolation of tumor mesenchymal stem-like cells (tMSLCs), which play important roles in glioma progression. However, attempts to isolate tMSLCs from surgical specimens have not always been successful, and the reasons for this remain unclear. Considering that the amount of surgical high-grade glioma specimens varies, we hypothesized that larger surgical specimens would be better for tMSLC isolation.
Materials and Methods: We assessed 51 fresh, high-grade glioma specimens and divided them into two groups according to the success or failure of tMSLC isolation. The success of tMSLC isolation was confirmed by plastic adherence, presenting antigens, tri-lineage differentiation, and non-tumorigenicity. Differences in characteristics between the two groups were tested using independent two sample t-tests, chi-square tests, or Kaplan-Meier survival analysis.
Results: The mean specimen weights of the groups differed from each other (tMSLC-negative group: 469.9±341.9 mg, tMSLC positive group: 546.7±618.9 mg), but the difference was not statistically significant. The optimal cut-off value of specimen weight was 180 mg, and the area under the curve value was 0.599.
Conclusion: Our results suggested a minimum criterion for specimen collection, and found that the specimen amount was not deeply related to tMSLC detection. Collectively, our findings imply that the ability to isolate tMSLCs is determined by factors other than the specimen amount.
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참고문헌 (37)
참고문헌 신청
Kang SG / 2010 / Isolation and perivascular localization of mesenchymal stem cells from mouse brain / Neurosurgery 67:711~720
Lang FF / 2008 / Tumor-derived mesenchymal stem cells in human gliomas : isolation and biological properties / J Clin Oncol 26:2001
Hossain A / 2015 / Mesenchymal stem cells isolated from human gliomas increase proliferation and maintain stemness of glioma stem cells through the IL-6/gp130/STAT3 pathway / Stem Cells 33:2400~2415
Behnan J / 2014 / Recruited brain tumor-derived mesenchymal stem cells contribute to brain tumor progression / Stem Cells 32:1110~1123
Kim YG / 2013 / Existence of glioma stroma mesenchymal stemlike cells in Korean glioma specimens / Childs Nerv Syst 29:549~563
Lang FF / 2008 / Tumor-derived mesenchymal stem cells in human gliomas : isolation and biological properties / J Clin Oncol 26:2001
Hossain A / 2015 / Mesenchymal stem cells isolated from human gliomas increase proliferation and maintain stemness of glioma stem cells through the IL-6/gp130/STAT3 pathway / Stem Cells 33:2400~2415
Behnan J / 2014 / Recruited brain tumor-derived mesenchymal stem cells contribute to brain tumor progression / Stem Cells 32:1110~1123
Kim YG / 2013 / Existence of glioma stroma mesenchymal stemlike cells in Korean glioma specimens / Childs Nerv Syst 29:549~563
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