지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 778 - 785 (8page)
- DOI
- 10.3349/ymj.2017.58.4.778
이용수
초록· 키워드
오류제보하기
Purpose: Peramivir is the first intravenously administered neuramidase inhibitor for immediate delivery of an effective single-dose treatment in patients with influenza. However, limited data are available on intravenous (IV) peramivir treatment compared to oral oseltamivir for these patients.
Materials and Methods: With a systematic review and meta-analysis, we compared the efficacy of IV peramivir with oral oseltamivirfor treatment of patients with seasonal influenza. MEDLINE, EMBASE, and Cochrane Central Register were searched for relevantclinical trials.
Results: A total of seven trials [two randomized controlled trials (RCTs) and five non-randomized observational trials] involving 1676 patients were finally analyzed. The total number of peramivir- and oseltamivir-treated patients was 956 and 720, respectively.
Overall, the time to alleviation of fever was lower in the peramivir-treated group compared with the oseltamivir-treated group [mean difference (MD), -7.17 hours; 95% confidence interval (CI) -11.00 to -3.34]. Especially, pooled analysis of observational studies(n=4) and studies of outpatients (n=4) demonstrated the superiority of the peramivir-treated group (MD, -7.83 hours; 95% CI -11.81 to -3.84 and MD, -7.71 hours; 95% CI -11.61 to -3.80, respectively). Mortality, length of hospital stay, change in virus titer 48 hours after admission, and the incidence of adverse events in these patients were not significantly different between the two groups.
Conclusion: IV peramivir therapy might reduce the time to alleviation of fever in comparison with oral oseltamivir therapy in patientswith influenza; however, we could not draw clear conclusions from a meta-analysis because of the few RCTs available and methodological limitations.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
2012 / Vaccines against influenza WHO position paper–November 2012 / Wkly Epidemiol Rec 87:461~476
Centers for Diseases Control and Prevention / Vaccine Recommendations of the ACIP
Wester A / 2016 / Peramivir injection in the treatment of acute influenza:a review of the literature / Infect Drug Resist 9:201~214
Birnkrant D / 2009 / The emergency use authorization of peramivir for treatment of 2009 H1N1 influenza / N Engl J Med 361:2204~2207
Kohno S / 2010 / Efficacy and safety of intravenous peramivir for treatment of seasonal influenza virus infection / Antimicrob Agents Chemother 54:4568~4574
Centers for Diseases Control and Prevention / Vaccine Recommendations of the ACIP
Wester A / 2016 / Peramivir injection in the treatment of acute influenza:a review of the literature / Infect Drug Resist 9:201~214
Birnkrant D / 2009 / The emergency use authorization of peramivir for treatment of 2009 H1N1 influenza / N Engl J Med 361:2204~2207
Kohno S / 2010 / Efficacy and safety of intravenous peramivir for treatment of seasonal influenza virus infection / Antimicrob Agents Chemother 54:4568~4574
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Oseltamivir를 투약한 양성대조군과 비교한 인플루엔자의 한약 치료 효과 -RCT 연구를 중심으로-
대한한방소아과학회지
2019 .01
-
소아 입원환자에서의 A형 및 B형 인플루엔자 임상 비교
Pediatric Infection and Vaccine
2017 .01
-
독감의 치료와 예방
대한의사협회지
2018 .01
-
A Case of Influenza Associated Fulminant Myocarditis Successfully Treated with Intravenous Peramivir
Infection and Chemotherapy
2015 .01
-
Psychiatric Symptoms in a Patient with Influenza A (H1N1) Treated with Oseltamivir (Tamiflu): A Case Report
Clinical Psychopharmacology and Neuroscience
2015 .01
-
Morin Hydrate Inhibits Influenza Virus entry into Host Cells and Has Anti-inflammatory Effect in Influenza-infected Mice
Immune Network
2020 .08
-
Oseltamivir 복용 이후 소아에서 발생한 이상행동 및 그 인과성 평가
한국임상약학회지
2019 .01
-
단일 병원에서 2013–2015년에 유행한 인플루엔자 A형과 B형의 임상 양상 및 치료반응의 차이
Pediatric Infection and Vaccine
2017 .01
-
인플루엔자
대한내과학회지
2017 .01
-
Estimating Influenza-associated Mortality in Korea: The 2009-2016 Seasons
예방의학회지
2019 .01
-
Interim Estimates of 2023–2024 Seasonal Influenza Vaccine Effectiveness Among Adults in Korea
Journal of Korean Medical Science
2024 .04
-
Incidence, Severity, and Mortality of Influenza During 2010–2020 in Korea: A Nationwide Study Based on the Population-Based National Health Insurance Service Database
Journal of Korean Medical Science
2023 .02
-
All-Cause and Cause-Specific Mortality Attributable to Seasonal Influenza: A Nationwide Matched Cohort Study
Journal of Korean Medical Science
2023 .06
-
The 2009 H1N1 Pandemic Influenza in Korea
Tuberculosis and Respiratory Diseases
2016 .01
-
Comparative Evaluation of the STANDARD F Influenza A/B FIA Test with the Sofia Influenza A+B FIA and SD BIOLINE Influenza Ag A/B/A(H1N1) tests for Influenza A Virus Detection
Annals of Clinical Microbiology
2021 .01
-
The Impact of Social Distancing on the Transmission of Influenza Virus, South Korea, 2020
Osong Public Health and Research Persptectives
2020 .01
-
The Korean Influenza National Immunization Program: History and Present Status
Infection and Chemotherapy
2017 .01
-
독감 예방접종군과 미접종군 간의 독감의사질병 발생 차이 비교
기초간호자연과학회지
2016 .01
-
영상 인식 기반 신속 인플루엔자 자동 판독 기법 개발
의공학회지
2019 .01
-
신생아에서의 인플루엔자와 COVID-19 혼합감염의 증례
Allergy Asthma & Respiratory Diseases
2023 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0