지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 1,361 - 1,369 (9page)
- DOI
- 10.1007/s13258-021-01164-2
이용수
초록· 키워드
오류제보하기
Background The potential role of HIST1H2BN in prostate cancer remains unclear.
Objective To evaluate the carcinogenic role of HIST1H2BN in prostate cancer.
Methods The expression of HIST1H2BN in prostate cancer was analyzed using TCGA database and clinical samples. The roles and mechanisms of HIST1H2BN were investigated in DU145 and PC3 cells.
Results HIST1H2BN was signifcantly upregulated in prostate cancer. HIST1H2BN knockdown inhibited cell proliferation, migration and EMT phenotype in prostate cancer cells. Downregulating HIST1H2BN diminished the expression and binding activity of NF-κB p65, then infuenced the expression of MMP2 and MMP9.
Conclusion This is the frst study to elaborate a HIST1H2BN-NF-κB-EMT regulatory axis in oncogenesis, indicating that HIST1H2BN might be potential therapeutic target for prostate cancer.
목차
등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
Alaseem A / 2019 / Matrix metalloproteinases : a challenging paradigm of cancer management / Semin Cancer Biol 56:100~115
Allemani C / 2018 / Global surveillance of trends in cancer survival 2000-14(CONCORD-3) : analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries / Lancet 391:1023~1075
Brabletz T / 2012 / To diferentiate or not–routes towards metastasis / Nat Rev Cancer 12:425~436
Cang S / 2016 / Hypoacetylation, hypomethylation, and dephosphorylation of H2B histones and excessive histone deacetylase activity in DU-145 prostate cancer cells / J Hematol Oncol 9:3
Chen W / 2016 / Cancer statistics in China, 2015 / Cancer J Clin 66:115~132
Allemani C / 2018 / Global surveillance of trends in cancer survival 2000-14(CONCORD-3) : analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries / Lancet 391:1023~1075
Brabletz T / 2012 / To diferentiate or not–routes towards metastasis / Nat Rev Cancer 12:425~436
Cang S / 2016 / Hypoacetylation, hypomethylation, and dephosphorylation of H2B histones and excessive histone deacetylase activity in DU-145 prostate cancer cells / J Hematol Oncol 9:3
Chen W / 2016 / Cancer statistics in China, 2015 / Cancer J Clin 66:115~132
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Vibrational properties of h-BN and h-BN-graphene heterostructures probed by inelastic electron tunneling spectroscopy
한국진공학회 학술발표회초록집
2016 .08
-
BN과 AlN 시트에 다양한 기체(COx, NOx, SOx)의 흡착에 관한 이론 연구
대한화학회지
2017 .02
-
Theoretical approach to bandgap control in graphene/h-BN heterojunctions
한국진공학회 학술발표회초록집
2016 .08
-
Visceral Obesity Assessment by MRI and Prostate Cancer Risk
Journal of Magnetics
2019 .12
-
Electronic structure and chemical imaging of smart low dimensional materials : graphene, h-BN, MoS₂ and many others
한국진공학회 학술발표회초록집
2016 .08
-
Growth of graphene/h-BN in-plane heterostructure by adjusting area ration on single crystal Ge substrate
한국진공학회 학술발표회초록집
2019 .08
-
Two-dimensional h-BN/MoSe₂ heterostructures based phototransistors
한국진공학회 학술발표회초록집
2016 .08
-
Association between glutathione S-transferases M1, T1 and P1 gene polymorphisms and prostate cancer in Koreans
Genes & Genomics
2016 .01
-
High quality topological insulator Bi₂Se₃ grown on h-BN using molecular beam epitaxy
한국진공학회 학술발표회초록집
2016 .08
-
Magnetic Properties of Ni/BN/Co Trilayer Structure: A First Principles Study
Journal of Magnetics
2015 .09
-
질화붕소 절연층을 이용한 그래핀/다공성 실리콘 태양전지 특성 연구
새물리
2021 .06
-
Van der Waals heterostructure with direct transfer of h-BN on as grown single crystalline graphene
한국진공학회 학술발표회초록집
2018 .08
-
Investigation of Magnetic Anisotropy in Ultra-thin Co Films Grown on 2-D Materials
한국자기학회 학술연구발표회 논문개요집
2021 .11
-
Transparent and Flexible Field Effect Transistor based on Two-Dimensional Materials
한국진공학회 학술발표회초록집
2016 .02
-
ON THE DIOPHANTINE EQUATION (an)x + (bn)y = (cn)z
대한수학회보
2015 .01
-
Molecular fossils “pseudogenes” as functional signature in biological system
Genes & Genomics
2020 .01
-
Diminished Coulomb scattering in MoTe₂ multilayer transistors : the effects of h-BN underlay and Al₂O₃ top passivation
한국진공학회 학술발표회초록집
2016 .08
-
Study on the possibility of using Selenoproteins as biomarkers for prostate and stomach cancers in Korean patients
한국분석과학회 학술대회
2015 .05
-
Characterization and surface engineering of two-dimensional atomic crystals
한국진공학회 학술발표회초록집
2015 .08
-
High Performance Bioelectronic Nose for detecting the Liquid and Gaseous Cadaverine
한국진공학회 학술발표회초록집
2021 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0