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자료유형
학술저널
저자정보
Yazmín Hernández‑Díaz (Universidad Juárez Autónoma de Tabasco) Thelma Beatriz González‑Castro (Universidad Juárez Autónoma de Tabasco) Isela Esther Juárez‑Rojop (Universidad Juárez Autónoma de Tabasco) Carlos Alfonso Tovilla‑Zárate (Universidad Juárez Autónoma de Tabasco) María Lilia López‑Narváez (Hospital General de Yajalón “Manuel Velasco Siles”) Alma Delia Genis‑Mendoza (Servicios de Atención Psiquiátrica) Ana Fresan (Instituto Nacional de Psiquiatría “Ramón de La Fuente Muñíz”) Humberto Nicolini (Servicios de Atención Psiquiátrica)
저널정보
한국유전학회 Genes & Genomics Genes & Genomics Vol.43 No.11
발행연도
2021.11
수록면
1,339 - 1,349 (11page)
DOI
10.1007/s13258-021-01133-9

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Background Several studies have evaluated the possible association between polymorphisms or variants in Corticotropinreleasing hormone 1 receptor gene (CRHR1) with depression; however, results remain contradictory and heterogeneous. Objective To our knowledge, we conducted the frst comprehensive systematic review and meta-analysis evaluating the association of the CRHR1 gene and the risk of depression. Methods A search online was conducted in databases for any CRHR1 genetic association studies in depression. Data were extracted for evaluation of pooled estimates using meta-analytic techniques. Statistical analyses were performed using the Comprehensive Meta-analysis, v2.0 software. Result A total of 1403 cases and 2353 mentally healthy controls were included in this study. We found a signifcant association of rs242941, rs1876828 and rs242939 variants of the CRHR1 gene with depression. No association of CRHR1 rs110402 and depression was observed. Conclusion Our meta-analysis shows that some variants of the CRHR1 gene (rs242941, rs1876828 and rs242939) might confer susceptibility to depression. Further studies with larger sample sizes need to be conducted.

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