메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
이윤범 (대구가톨릭대학교 화학물질독성평가학과) 김근우 (대구가톨릭대학교 의료보건산업대학원 화학물질독성평가학과) 송영민 (대구가톨릭대학교 의료보건산업대학원 화학물질독성평가학과) 한영훈 (대구가톨릭대학교 의료보건산업대학원 화학물질독성평가학과) 하창수 (대구가톨릭대학교 의료보건산업대학원 화학물질독성평가학과) 이지선 (대구가톨릭대학교 GLP 센터) 김민희 (대구가톨릭대학교 GLP센터) 손혜영 (대구가톨릭대학교 GLP 센터) 이기용 (대구가톨릭대학교) 허용 (대구가톨릭대학교) 김창열 (대구가톨릭대학교)
저널정보
한국환경보건학회 한국환경보건학회지 한국환경보건학회지 제46권 제6호
발행연도
2020.12
수록면
667 - 675 (9page)
DOI
10.5668/JEHS.2020.46.6.667

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Objectives: Exposure to fine dust (PM10) could contribute to the occurrence of cardiovascular disease or respiratory abnormalities. Since garlic is known to possess an anti-oxidative stress effect, the present study was performed to evaluate the effect of garlic intake on fine dust-mediated pulmonary toxicity. Methods: Rats were intratracheally instilled with fine dust at 15 mg/kg body weight (BW)/day for five days following five-day intragastric intubation of garlic at 0.7 or 1.4 g/kgBW/day, or 13.1 mg/kgBW/day S-allyl-cysteine (SAC) as a reference component in garlic. Blood and bronchoalveolar lavage fluid (BALF) were collected. Results: Deposit of fine dust was visually and histopathologically observed in the lungs. Body weight gain during the instillation period was significantly lowered in all the groups instilled with fine dust. Neutrophil numbers in blood were significantly elevated in the fine dust alone group, but this alteration was diminished in the groups administered with garlic. Levels of serum glutathione were lower in the rats instilled with fine dust alone, and this decrease in the glutathione level seems dose-dependently compensated among the groups administered with garlic. Similar findings were observed in the BALF with statistical significance. Typical pulmonary histopathological observation related with inflammation was demonstrated in the lungs of the rats exposed to fine dust alone, whereas such histopathologic findings were not improved in the groups administered with garlic. Conclusion: The present study suggests that garlic intake could alleviate fine dust-mediated pulmonary or systemic toxicities. Further investigation is necessary to delineate the mechanism of garlic-mediated effects on pulmonary function.

목차

등록된 정보가 없습니다.

참고문헌 (36)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0