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논문 기본 정보

자료유형
학술저널
저자정보
Kim Hyo-Eun (Department of Life Science Multidisciplinary Genome Institute Hallym University Chuncheon Gangwon-d) Kim Jongjin (Department of Surgery Seoul Metropolitan Government Seoul National University Boramae Medical Cente) Maeng Sejung (Department of Surgery Seoul Metropolitan Government Seoul National University Boramae Medical Cente) Oh Bumjo (Department of Family Medicine Seoul Metropolitan Government Seoul National University Boramae Medic) Hwang Ki-Tae (Department of Surgery Seoul Metropolitan Government Seoul National University Boramae Medical Cente) 김봉수 (한림대학교)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제12호
발행연도
2021.12
수록면
1,643 - 1,655 (13page)
DOI
10.4014/jmb.2106.06039

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Recent studies have reported dysbiosis of the microbiome in breast tissue collected from patients with breast cancer and the association between the microbiota and disease progression. However, the role of the microbiota in breast tissue remains unclear, possibly due to the complexity of breast cancer and various factors, including racial and geographical differences, influencing microbiota in breast tissue. Here, to determine the potential role of microbiota in breast tumor tissue, we analyzed 141 tissue samples based on three different tissue types (tumor, adjacent normal, and lymph node tissues) from the same patients with breast cancer in Korea. The microbiota was not simply distinguishable based on tissue types. However, the microbiota could be divided into two cluster types, even within the same tissue type, and the clinicopathologic factors were differently correlated in the two cluster types. Risk of regional recurrence was also significantly different between the microbiota cluster types (p = 0.014). In predicted function analysis, the pentose and glucuronate interconversions were significantly different between the cluster types (q < 0.001), and Enterococcus was the main genus contributing to these differences (q < 0.01). Results showed that the microbiota of breast tissue could interact with the host and influence the risk of regional recurrence. Although further studies would be recommended to validate our results, this study could expand our understanding on the breast tissue microbiota, and the results might be applied to develop novel prediction methods and treatments for patients with breast cancer.

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