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논문 기본 정보

자료유형
학술저널
저자정보
Tajdozian Hanieh (Department of Microbiology and Immunology College of Medicine Soonchunhyang University Cheonan 3115) Seo Hoonhee (Probiotics Microbiome Convergence Center Asan 31538 Chungnam Republic of Korea) Kim Sukyung (Probiotics Microbiome Convergence Center Asan 31538 Chungnam Republic of Korea) Rahim Md Abdur (Department of Microbiology and Immunology College of Medicine Soonchunhyang University Cheonan 3115) Lee Saebim (Probiotics Microbiome Convergence Center Asan 31538 Chungnam Republic of Korea) 송호연 (순천향대학교)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제10호
발행연도
2021.10
수록면
1,383 - 1,392 (10page)
DOI
10.4014/jmb.2103.03014

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Carbapenem-resistant Enterobacteriaceae (CRE) that produce Klebsiella pneumoniae carbapenemase are increasingly reported worldwide and have become more and more resistant to nearly all antibiotics during the past decade. The emergence of K. pneumoniae strains with decreased susceptibility to carbapenems, which are used as a last resort treatment option, is a significant threat to hospitalized patients worldwide as K. pneumoniae infection is responsible for a high mortality rate in the elderly and immunodeficient individuals. This study used Lactobacillus fermentum as a candidate probiotic for treating CRE-related infections and investigated its effectiveness. We treated mice with L. fermentum originating from the vaginal fluid of a healthy Korean woman and evaluated the Lactobacilli’s efficacy in preventive, treatment, nonestablishment, and colonization mouse model experiments. Compared to the control, pre-treatment with L. fermentum significantly reduced body weight loss in the mouse models, and all mice survived until the end of the study. The oral administration of L. fermentum after carbapenemresistant Klebsiella (CRK) infection decreased mortality and illness severity during a 2-week observation period and showed that it affects other strains of CRK bacteria. Also, the number of Klebsiella bacteria was decreased to below 5.5 log10 CFU/ml following oral administration of L. fermentum in the colonization model. These findings demonstrate L. fermentum’s antibacterial activity and its potential to treat CRE infection in the future.

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