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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제9호
- 발행연도
- 2021.9
- 수록면
- 1,256 - 1,261 (6page)
- DOI
- 10.4014/jmb.2106.06047
이용수
초록· 키워드
오류제보하기
Rubus coreanus Miquel (bokbunja), Korean black raspberry, is known to possess various phytochemicals that exert antioxidative, anti-inflammatory, and anti-cancer effects. However, most studies on Rubus coreanus Miquel have been performed with the solvent extracts and/or a single component to demonstrate the efficacy, while studies evaluating the effect of the whole fructus of Rubus coreanus Miquel are limited. In this study, therefore, we employed the isoproterenol (IPN)- induced myocardial infarction model and investigated the effect of freeze-dried powder of Rubus coreanus Miquel (RCP) on oxidative stress and prevention of organ damage. Oral administration of RCP reduced the level of toxicity markers, alanine transaminase (ALT), aspartate transaminase (AST), and lactate dehydrogenase (LDH) without affecting body weight and diet intake. The oxidative stress marker glutathione (GSH) increased about 45% and malonaldehyde (MDA) decreased about 27% compared to the IPN group with RCP-H (3%) administration. By histological analysis, IPN induced significant myocardial damage in the heart and vascular injury in the liver, and RCP administration ameliorated the damages in a dose-dependent manner. Taken together, RCP activated the antioxidant system leading to prevention of damage to organs by IPN in rats, making it possible to expect beneficial efficacies by consuming the whole fructus of Rubus coreanus Miquel.
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등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Park JH / 2006 / Induction of heme oxygenase-1 mediates the anti-inflammatory effects of the ethanol extract of Rubus coreanus in murine macrophages / Biochem. Biophys. Res. Commun 351:146~152
이정은 / 2014 / Anti-inflammatory effects of Rubus coreanus Miquel through inhibition of NF-κB and MAP Kinase / Nutrition Research and Practice 8(5):501~508
Bhandary B / 2012 / Water extracts of immature Rubus coreanus regulate lipid metabolism in liver cells / Biol. Pharm. Bull 35:1907~1913
Lee KH / 2020 / Unripe Rubus coreanus miquel extract containing ellagic acid regulates AMPK, SREBP-2, HMGCR, and INSIG-1 signaling and cholesterol metabolism in vitro and in vivo / Nutrients 12:610
Do SH / 2008 / Bone-protecting effect of Rubus coreanus by dual regulation of osteoblasts and osteoclasts / Menopause 15:676~683
이정은 / 2014 / Anti-inflammatory effects of Rubus coreanus Miquel through inhibition of NF-κB and MAP Kinase / Nutrition Research and Practice 8(5):501~508
Bhandary B / 2012 / Water extracts of immature Rubus coreanus regulate lipid metabolism in liver cells / Biol. Pharm. Bull 35:1907~1913
Lee KH / 2020 / Unripe Rubus coreanus miquel extract containing ellagic acid regulates AMPK, SREBP-2, HMGCR, and INSIG-1 signaling and cholesterol metabolism in vitro and in vivo / Nutrients 12:610
Do SH / 2008 / Bone-protecting effect of Rubus coreanus by dual regulation of osteoblasts and osteoclasts / Menopause 15:676~683
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