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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제51권 제5호
- 발행연도
- 2021.9
- 수록면
- 555 - 570 (16page)
- DOI
- 10.1007/s40005-021-00543-x
이용수
초록· 키워드
오류제보하기
Background Fixed dose combination (FDC) products are common in the treatment of various disease such as hypertension, diabetes, HIV and HCV, Pain, Respiratory disease for improving therapeutic efficacy and tolerability. They make it possible to combine more than two drug molecules with optimal doses, dosage form and optimize the treatment.
Area covered This review provides discussions of the FDC application in variety of disease. various formulation technologies such as bilayer system, active film coating, co-crystal, multi-particulate system, Hot-melt co-extrusion, hot fusion method, spray drying and 3D-printing that consider characteristics of each active pharmaceutical ingredient (API) in FDC to maximize the benefits and overcome the challenges of developing FDC products.
Expert opinion FDC has utilized as a promising dosage form to increase the oral absorption of drugs. From beneficial perspective, they offer efficacy and safety improvement, product exclusivity, patient compliance, medicinal cost reduction.
while disadvantage perspectives such as a lack of dose flexibility, drug interaction, difference dosage regimen, dose difference and difference of physicochemical properties should be considered for the use of FDC, differences in individual drug characteristics, drug release profiles, therapeutic dose, and solubility should be considered for FDCs design and formulation.
목차
등록된 정보가 없습니다.
참고문헌 (143)
참고문헌 신청
Abdelquader MM / 2019 / Inhibition of cocrystallization of olmesartan medoxomil and hydrochlorothiazide for enhanced dissolution rate in their fixed dose combination / AAPS PharmSciTech 20:3
Abdul S / 2004 / A flexible technology for modified release of drugs: multi layered tablets / J Control Release 97:393~405
Abebe A / 2014 / Review of bilayer tablet technology / Int J Pharm 461:549~558
Akseli I / 2010 / Mechanical property characterization of bilayered tablets using nondestructive air-coupled acoustics / AAPS PharmSciTech 11:90~102
Albanna AS / 2013 / Fixed-dose combination antituberculosis therapy: a systematic review and meta-analysis / Eur Respir J 42:721~732
Abdul S / 2004 / A flexible technology for modified release of drugs: multi layered tablets / J Control Release 97:393~405
Abebe A / 2014 / Review of bilayer tablet technology / Int J Pharm 461:549~558
Akseli I / 2010 / Mechanical property characterization of bilayered tablets using nondestructive air-coupled acoustics / AAPS PharmSciTech 11:90~102
Albanna AS / 2013 / Fixed-dose combination antituberculosis therapy: a systematic review and meta-analysis / Eur Respir J 42:721~732
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