지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제48권 제3호
- 발행연도
- 2018.5
- 수록면
- 257 - 267 (11page)
- DOI
- 10.1007/s40005-017-0304-1
이용수
초록· 키워드
오류제보하기
An attempt was made to formulate mesalamineloaded alginate microspheres by emulsion cross linking method for local treatment of ulcerative colitis. Microspheres were filled in HPMC capsules enteric coated with Eudragit FS-30D. The effect of process variables like drug-alginate concentration ratio and emulsifier concentration was optimized. Microspheres were evaluated for particle size, shape and entrapment efficiency. Spherical shaped microspheres were confirmed by scanning electron microscopy. In vitro drug release study showed a burst drug release pattern in the initial hour necessitating encapsulation of alginate microspheres. In vivo study in rats performed by colonic inflammatory lesions demonstrated remarkable reduction in ulcer index treated with microspheres. Histopathological study confirmed no signs of ulceration or bleeding. Microspheres (drug:alginate concentration, 1:1) was then filled in HPMC capsule shells, enteric coated with Eudragit FS 30D to gain 30 mg weight. Due to solubility of Eudragit FS30D above pH 7, an encapsulated system released alginate microspheres at colon region. Capsules with weight gain of 30 mg coating polymer (B3) resisted the drug release at intestinal region for about 6 h with 10% drug release. In vitro drug release of formulation B3 showed 64.89 and 90.52% drug release within 10 h, in phosphate buffer pH 7.4 and in presence of rat faecal content in simulated colonic fluid, respectively.
The later rapid drug release was due to action of colonic microflora at alginate microspheres. Therefore, mesalamine-loaded alginate microspheres enteric coated in HPMC capsules can be potential delivery system for local treatment of ulcerative colitis.
목차
등록된 정보가 없습니다.
참고문헌 (47)
참고문헌 신청
Ahmed AE / 2012 / Influence of some formulation variables on the optimization of pH-dependent, colon-targeted, sustained-release mesalamine microspheres / AAPS PharmSciTech 13(1):75~84
Alhnan MA / 2011 / Engineering polymer blend microparticles: an investigation into the influence of polymer blend distribution and interaction / Eur J Pharm Sci 42(1-2):30~36
Ashford M / 1993 / An in vivo investigation into the suitability of pH dependent polymers for colon targeting / Int J Pharm 95:193~199
Ashford M / 1993 / An in vitro investigation into the suitability of pH dependent polymers for colon targeting / Int J Pharm 91:241~245
Ashford M / 1994 / Studies on pectin formulation for colonic drug delivery / J Control Release 30:225~232
Alhnan MA / 2011 / Engineering polymer blend microparticles: an investigation into the influence of polymer blend distribution and interaction / Eur J Pharm Sci 42(1-2):30~36
Ashford M / 1993 / An in vivo investigation into the suitability of pH dependent polymers for colon targeting / Int J Pharm 95:193~199
Ashford M / 1993 / An in vitro investigation into the suitability of pH dependent polymers for colon targeting / Int J Pharm 91:241~245
Ashford M / 1994 / Studies on pectin formulation for colonic drug delivery / J Control Release 30:225~232
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Development of vildagliptin loaded Eudragit® microspheres by screening design: in vitro evaluation
Journal of Pharmaceutical Investigation
2018 .11
-
Incorporation of amoxicillin-loaded microspheres in mineral trioxide aggregate cement: an in vitro study
Restorative Dentistry and Endodontics
2020 .01
-
Formulation of floating metronidazole microspheres using cassava starch (Manihot esculenta) as polymer
Journal of Pharmaceutical Investigation
2017 .09
-
스프레이 건조법을 이용한 PMMA/TiO<sub>2</sub> 다공성 입자 제조 및 특성 연구
대한화장품학회지
2016 .01
-
Development of ibuprofen microspheres using acetylated plantain starches as polymer for sustained release
Journal of Pharmaceutical Investigation
2018 .09
-
Physicochemical characterization of naproxen microcrystals for colon specific pulsatile drug delivery designed using pulsincap technique
Journal of Pharmaceutical Investigation
2019 .01
-
Preparation and evaluation of enrofloxacin microspheres and tissue distribution in rats
Journal of Veterinary Science
2015 .06
-
Histopathological examination: evaluation of tissue damage in pig kidneys by embolic microspheres
한국실험동물학회 학술발표대회 논문집
2022 .01
-
[Erratum]Detection of First-Line Anti-Tuberculosis Drug Resistance Mutations by Allele-Specific Primer Extension on a Microsphere-Based Platform
Annals of Laboratory Medicine
2017 .01
-
Anticancer activity of drug-loaded calcium phosphate nanocomposites against human osteosarcoma
생체재료학회지
2017 .01
-
New blends of hydroxypropylmethylcellulose and Gelucire 44/14: physical property and controlled release of drugs with different solubility
Journal of Pharmaceutical Investigation
2018 .05
-
Development of a patient-centric formulation of tegoprazan, a novel potassium-competitive acid blocker, using modified-release drug-coated pellets
Journal of Pharmaceutical Investigation
2022 .09
-
Factors related to Quality of Life of Patients with Ulcerative Colitis
성인간호학회 학술대회
2015 .04
-
Ulcerative Colitis and Patient’s Quality of Life, Especially in Early Stage
Gut and Liver
2022 .05
-
Layer-by-layer assembled polymeric thin films as prospective drug delivery carriers: design and applications
생체재료학회지
2018 .12
-
신생 혈관과 항균 능력을 지닌 이중 이온 전달가능 실리카 기반 마이크로 입자
대한치과재료학회 학술대회
2019 .04
-
Colon Capsule Endoscopy for Inflammatory Bowel Disease
Clinical Endoscopy
2020 .01
-
인체 내부 환경 변화 모사에 따른삼투압 기반 약물주입펌프의 기능 평가 연구
의공학회지
2015 .01
-
In vivo tumour imaging employing regional delivery of novel Gallium radiolabelled polymer composites
생체재료학회지
2021 .01
-
Is the Long-term Disease Course of Elderly-Onset Ulcerative Colitis Different from That of Non-Elderly-Onset Ulcerative Colitis?
Gut and Liver
2021 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0