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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제47권 제4호
- 발행연도
- 2017.7
- 수록면
- 335 - 347 (13page)
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초록· 키워드
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In the present research, methotrexate (MTX) loaded ultra-small PLGA nanoparticles were formulated with an aim of passively targeting the bone for effective treatment of metastatic condition. Formulations were prepared by using 32 factorial designs to evaluate the impact of the formulation variables on the dependant variables.
The prepared formulations were subjected for nano-characterization and in vitro haemolysis evaluation. Nanocharacterization with Malvern particle size analyser depicted a particle size below 10 nm, zeta potential ([30) indicating a very high stability with entrapment efficiency of formulation ([60 %) and drug release of [80 % sustaining for 7 days. Kinetic modelling showed that the formulations showed best fit for Korsmeyer Peppas model with r value of 0.9875. TEM and AFM studies showed ultra small nanoparticles with a spherical shape and smooth surface respectively. In-vitro bone affinity studies showed that the nanoformulation had higher affinity for Hydroxyapatite than the pure drug alone. In-vitro haemolytic assay showed a reduced haemotoxicity of the MTX when encapsulated in a nanosystem rather the pure drug.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Bhandari KH / 2010 / Synthesis, characterization and in vitro evaluation of a bone targeting delivery system for salmon Calcitonin / Int J Pharm 394:26~34
Chaudhari KR / 2012 / Bone metastasis targeting: a novel approach to reach bone using Zoledronate anchored PLGA nanoparticle as carrier system loaded with Docetaxel / J Control Release 158:470~478
Chen Y / 2013 / Pluronic mixed micelles overcoming methotrexate multidrug resistance: in vitro and in vivo evaluation / Int J Nanomedicine 8:1463~1476
Dash N / 2015 / Design, optimization and evaluation of glipizide solid self-nanoemulsifying drug delivery for enhanced solubility and dissolution / Saudi Pharm J 23:528~540
Fan W / 2012 / Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique / Colloids Surf B Biointerfaces 90:21~27
Chaudhari KR / 2012 / Bone metastasis targeting: a novel approach to reach bone using Zoledronate anchored PLGA nanoparticle as carrier system loaded with Docetaxel / J Control Release 158:470~478
Chen Y / 2013 / Pluronic mixed micelles overcoming methotrexate multidrug resistance: in vitro and in vivo evaluation / Int J Nanomedicine 8:1463~1476
Dash N / 2015 / Design, optimization and evaluation of glipizide solid self-nanoemulsifying drug delivery for enhanced solubility and dissolution / Saudi Pharm J 23:528~540
Fan W / 2012 / Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique / Colloids Surf B Biointerfaces 90:21~27
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