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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 1 - 11 (11page)
- DOI
- 10.1038/s12276-021-00648-1
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In this study, we hypothesized that deregulation in the maintenance of the pool of coenzyme A (CoA) may play a crucial role in thepathogenesis of nonalcoholic fatty liver disease (NAFLD). Specific deletion of Acot12 (Acot12?/?), the major acyl-CoA thioesterase,induced the accumulation of acetyl-CoA and resulted in the stimulation of de novo lipogenesis (DNL) and cholesterol biosynthesisin the liver. KEGG pathway analysis suggested PPARα signaling as the most significantly enriched pathway in Acot12?/? livers.
Surprisingly, the exposure of Acot12?/? hepatocytes to fenofibrate significantly increased the accumulation of acetyl-CoA andresulted in the stimulation of cholesterol biosynthesis and DNL. Interaction analysis, including proximity-dependent biotin identification (BioID) analysis, suggested that ACOT12 may directly interact with vacuolar protein sorting-associated protein 33A (VPS33A) and play a role in vesicle-mediated cholesterol trafficking and the process of lysosomal degradation of cholesterol inhepatocytes. In summary, in this study, we found that ACOT12 deficiency is responsible for the pathogenesis of NAFLD through the accumulation of acetyl-CoA and the stimulation of DNL and cholesterol via activation of PPARα and inhibition of cholesterol trafficking.
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