지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 1 - 11 (11page)
- DOI
- 10.1038/s12276-020-00533-3
이용수
초록· 키워드
오류제보하기
Eukaryotic sliding clamp proliferating cell nuclear antigen (PCNA) plays a critical role as a processivity factor for DNA polymerases and as a binding and acting platform for many proteins. The ring-shaped PCNA homotrimer and the DNA damage checkpoint clamp 9-1-1 are loaded onto DNA by clamp loaders. PCNA can be loaded by the pentameric replication factor C (RFC) complex and the CTF18-RFC-like complex (RLC) in vitro. In cells, each complex loads PCNA for different purposes; RFC-loaded PCNA is essential for DNA replication, while CTF18-RLC-loaded PCNA participates in cohesion establishment and checkpoint activation. After completing its tasks, PCNA is unloaded by ATAD5 (Elg1 in yeast)-RLC. The 9-1-1 clamp is loaded at DNA damage sites by RAD17 (Rad24 in yeast)-RLC. All five RFC complex components, but none of the three large subunits of RLC, CTF18, ATAD5, or RAD17, are essential for cell survival; however, deficiency of the three RLC proteins leads to genomic instability. In this review, we describe recent findings that contribute to the understanding of the basic roles of the RFC complex and RLCs and how genomic instability due to deficiency of the three RLCs is linked to the molecular and cellular activity of RLC, particularly focusing on ATAD5 (Elg1).
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Analysis of the RLC Characteristics of High Frequency Transformer
대한전기학회 학술대회 논문집
2019 .07
-
직렬 RLC 공진을 이용한 저전력 LED 구동회로
공학기술논문지
2016 .12
-
2차계 전역통과 필터 설계
한국조명·전기설비학회 학술대회논문집
2021 .05
-
우주방사선 환경 조사 및 RLC 수동부품 방사선 영향
한국신뢰성학회 학술대회논문집
2023 .11
-
Artificial Protein Complex via PCNA Scaffold for Self-Sufficient Biocatalysis
한국생물공학회 학술대회
2015 .10
-
RLC Fault Detection Based on Image Processing and Artificial Neural Network
INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGENT SYSTEMS
2019 .06
-
MCK 진동 시스템과 RLC 전기 회로의 상사성 연구
한국소음진동공학회 학술대회논문집
2018 .04
-
Semi-active Reaction Force Compensation (RFC) mechanism for a Linear Motor Motion Stage
대한기계학회 춘추학술대회
2015 .05
-
CPR 기기 제작을 위한 흉부 RLC 모델 분석
대한기계학회 춘추학술대회
2017 .04
-
Comparison of High Frequency Detailed Generator Models for Partial Discharge Localization
Journal of Electrical Engineering & Technology
2015 .07
-
A Virtual RLC Active Damping Method for LCL-Type Grid-Connected Inverters
JOURNAL OF POWER ELECTRONICS
2018 .09
-
E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factors
Experimental and Molecular Medicine
2019 .01
-
경량 직접충전 방식의 재생연료전지 개발
대한기계학회 춘추학술대회
2016 .12
-
Adaptive ARQ Method for Enhancements of LTE MAC Protocol
멀티미디어학회논문지
2016 .12
-
Design of Thin and Wideband Microwave Absorbers Using General Closed-Form Solutions
Journal of Electromagnetic Engineering And Science
2021 .11
-
Partial Discharge Localization Based on Detailed Models of Transformer and Wavelet Transform Techniques
Journal of Electrical Engineering & Technology
2015 .05
-
반발력 보상 기구가 적용된 공기 베어링 선형 모터 모션 스테이지
한국정밀공학회 학술발표대회 논문집
2015 .12
-
고속 네트워크 보안 장비를 위한 고속 정적 정책 검색 알고리즘
보안공학연구논문지
2018 .01
-
ATAD2 expression increases [18F]Fluorodeoxyglucose uptake value in lung adenocarcinoma via AKT-GLUT1/HK2 pathway
BMB Reports
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0