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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 179 - 187 (9page)
- DOI
- 10.14348/molcells.2018.2110
이용수
초록· 키워드
오류제보하기
Proteomic analysis of extracellular vesicles (EVs) from biological fluid is a powerful approach to discover potential biomarkers for human diseases including cancers, as EV secreted to biological fluids are originated from the affected tissue. In order to investigate significant molecules related to the pathogenesis of bladder cancer, EVs were isolated from patient urine which was analyzed by mass spectrometry based proteomics. Comparison of the EV proteome to the whole urine proteome demonstrated an increased number of protein identification in EV. Comparative MS analyses of urinary EV from control subjects and bladder cancer patients identified a total of 1,222 proteins. Statistical analyses provided 56 proteins significantly increased in bladder cancer urine, including proteins for which expression levels varied by cancer stage (P-value < 0.05). While urine represents a valuable, non-invasive specimen for biomarker discovery in urologic cancers, there is a high degree of intra- and inter-individual variability in urine samples. The enrichment of urinary EV demonstrated its capability and applicability of providing a focused identifi-cation of biologically relevant proteins in urological diseases.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Adada, M.M. / 2015 / Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion / FASEB J. 29:4654~4669
Beckham, C.J. / 2014 / Bladder cancer exosomes contain EDIL-3/Del1 and facilitate cancer progression / J. Urol. 192:583~592
Bramswig, K.H. / 2013 / Soluble carcinoembryonic antigen activates endothelial cells and tumor angiogenesis / Cancer Res. 73:6584~6596
Colas, E. / 2011 / Molecular markers of endometrial carcinoma detected in uterine aspirates / Int. J. Cancer 129:2435~2444
Frantzi, M. / 2015 / Developing proteomic biomarkers for bladder cancer: towards clinical application / Nat. Rev. Urol. 12:317~330
Beckham, C.J. / 2014 / Bladder cancer exosomes contain EDIL-3/Del1 and facilitate cancer progression / J. Urol. 192:583~592
Bramswig, K.H. / 2013 / Soluble carcinoembryonic antigen activates endothelial cells and tumor angiogenesis / Cancer Res. 73:6584~6596
Colas, E. / 2011 / Molecular markers of endometrial carcinoma detected in uterine aspirates / Int. J. Cancer 129:2435~2444
Frantzi, M. / 2015 / Developing proteomic biomarkers for bladder cancer: towards clinical application / Nat. Rev. Urol. 12:317~330
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