지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.2
- 수록면
- 127 - 133 (7page)
- DOI
- 10.14348/molcells.2018.2244
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초록· 키워드
오류제보하기
Chromatin remodeling factors are involved in many cellular processes such as transcription, replication, and DNA damage response by regulating chromatin structure. As one of chromatin remodeling factors, remodeling and spacing factor 1 (RSF1) is recruited at double strand break (DSB) sites and regulates ataxia telangiectasia mutated (ATM) -dependent checkpoint pathway upon DNA damage for the efficient repair. RSF1 is overexpressed in a variety of cancers, but regulation of RSF1 levels remains largely unknown. Here, we showed that protein levels of RSF1 chromatin remodeler are temporally upregulated in response to different DNA damage agents without changing the RSF1 mRNA level. In the absence of SNF2h, a binding partner of RSF1, the RSF1 protein level was significantly diminished. Intriguingly, the level of RSF1-3SA mutant lacking ATM-mediated phosphorylation sites significantly increased, and upregulation of RSF1 levels under DNA damage was not observed in cells overex-pressing ATM kinase. Furthermore, failure in the regulation of RSF1 level caused a significant reduction in DNA repair, whereas reconstitution of RSF1, but not of RSF1-3SA mutants, restored DSB repair. Our findings reveal that temporal regulation of RSF1 levels at its post-translational modification by SNF2h and ATM is essential for efficient DNA repair.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Aydin, O.Z. / 2014 / ISWI chromatin remodeling complexes in the DNA damage response / Cell Cycle 13:3016~3025
Beli, P. / 2012 / Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response / Mol. Cell 46:212~225
Ciccia, A. / 2010 / The DNA damage response: making it safe to play with knives / Mol. Cell 40:179~204
Gunn, A. / 2011 / Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context / J. Biol. Chem. 286:42470~42482
Helfricht, A. / 2013 / Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA doublestrand breaks to promote non-homologous end-joining / Cell Cycle 12:3070~3082
Beli, P. / 2012 / Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response / Mol. Cell 46:212~225
Ciccia, A. / 2010 / The DNA damage response: making it safe to play with knives / Mol. Cell 40:179~204
Gunn, A. / 2011 / Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context / J. Biol. Chem. 286:42470~42482
Helfricht, A. / 2013 / Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA doublestrand breaks to promote non-homologous end-joining / Cell Cycle 12:3070~3082
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