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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 485 - 494 (10page)
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Oleanolic acid (OA) has neurotrophic effects on neurons, although its use as a neurological drug requires further research. In the present study, we investigated the effects of OA and OA derivatives on the neuronal differentiation of rat hippocampal neural progenitor cells. In addition, we investigated whether the class II histone deacetylase (HDAC) 5 mediates the gene expression induced by OA. We found that OA and OA derivatives induced the formation of neurite spines and the expression of synapse-related molecules. OA and OA derivatives stimulated HDAC5 phosphorylation, and concurrently the nuclear export of HDCA5 and the expression of HDAC5 target genes, indicating that OA and OA derivatives induce neural differentiation and synapse formation via a pathway that involves HDAC5 phosphorylation.
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참고문헌 (35)
참고문헌 신청
Berridge, M. V. / 2005 / Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction / Biotechnol. Annu. Rev 11:127~152
Broide, R. S. / 2007 / Distribution of histone deacetylases 1-11 in the rat brain / J. Mol. Neurosci 31:47~58
Castro, A. J. / 2015 / The mechanism of action of ursolic acid as insulin secretagogue and insulinomimetic is mediated by cross-talk between calcium and kinases to regulate glucose balance / Biochim. Biophys. Acta 1850:51~61
Chawla, S. / 2003 / Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5 / J. Neurochem 85:151~159
Cho, S. O. / 2009 / Aralia cordata protects against amyloid beta protein (25-35)-induced neurotoxicity in cultured neurons and has antidementia activities in mice / J. Pharmacol. Sci 111:22~32
Broide, R. S. / 2007 / Distribution of histone deacetylases 1-11 in the rat brain / J. Mol. Neurosci 31:47~58
Castro, A. J. / 2015 / The mechanism of action of ursolic acid as insulin secretagogue and insulinomimetic is mediated by cross-talk between calcium and kinases to regulate glucose balance / Biochim. Biophys. Acta 1850:51~61
Chawla, S. / 2003 / Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5 / J. Neurochem 85:151~159
Cho, S. O. / 2009 / Aralia cordata protects against amyloid beta protein (25-35)-induced neurotoxicity in cultured neurons and has antidementia activities in mice / J. Pharmacol. Sci 111:22~32
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