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논문 기본 정보

자료유형
학술저널
저자정보
Sepiso K. Masenga (Department of Biomedical Sciences School of Health Sciences University of Zambia) Leta Pilic (Faculty of Sport Health and Applied Science St. Mary’s University) Benson M. Hamooya (HAND Research Group School of Medicine and Health Sciences Mulungushi University) Selestine Nzala (School of Public Health and School of Medicine University of Zambia) Douglas C. Heimburger (School of Public Health and School of Medicine University of Zambia) Wilbroad Mutale (School of Public Health and School of Medicine University of Zambia) John R. Koethe (Department of Medicine Vanderbilt Institute for Global Health and Vanderbilt University Medical Cen) Annet Kirabo (Department of Medicine Vanderbilt Institute for Global Health and Vanderbilt University Medical Cen) Sody M. Munsaka (Department of Biomedical Sciences School of Health Sciences University of Zambia) Fernando Elijovich (Department of Medicine Vanderbilt Institute for Global Health and Vanderbilt University Medical Cen)
저널정보
대한고혈압학회 Clinical Hypertension Clinical Hypertension 제28권
발행연도
2022.1
수록면
25 - 25 (1page)
DOI
10.1186/s40885-022-00209-2

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High blood pressure (BP) is associated with high-salt consumption especially in sub-Saharan Africa. Although the pressor effect of salt is viewed as a chronic effect, some studies suggest that a salty meal may increase BP immediately in some individuals, and that this effect may cause endothelial dysfunction. Therefore, the aim of our research was to study the immediate pressor response to oral salt (IPROS) and its determinants, with the expectation that a simple methodology may be devised to diagnose it in the clinic or in low-resource environments.We conducted a time series trial at Livingstone Central Hospital. We present data in 127 normotensive participants who ingested 2?g of sodium chloride; their BP was monitored for 120?minutes in intervals of 10?minutes. Sociodemographic and clinical data were collected. Descriptive and inferential statistics were used for analyses of data.Median age was 30?years (interquartile range, 22?46?years) and 52% were female patients. An increase of ≥10?mmHg in mean arterial pressure (MAP), considered a clinically significant IPROS, was present in 62% of participants. Systolic BP 30?minutes after the salt load was a significant predictor of IPROS, avoiding the need to calculate MAP in the clinic setting.We confirm the presence of an IPROS in a high proportion (62%) of otherwise normotensive participants. The average time course for this response was 30?minutes and its duration was sustained for the 120-minutes period of study in most of the participants. Prediction of IPROS by ?SBP (change in systolic blood pressure) at 30?minutes allows for easy assessment of possible responder status in the clinic. Our data indicate that the IPROS to oral salt-loads in the range currently consumed by the Western world and African populations in single meals may increase the 24-hour BP load, which is a risk factor for hypertension and target organ damage. The relevance of our findings indicates the need to include dietary sodium assessment in the diagnosis, prevention, and management of high BP.
#Immediate pressor response #Blood pressure #Systolic pressure #Arterial pressure #Sodium chloride #Hypertension #Pulse pressure

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