Malignant Apocrine Lesions of the Breast: Multimodality Imaging Findings and Biologic Features

이효재; 강승완; 이종은; 정원기; 이지신; 박민호; 임효순

doi:10.4048/jbc.2022.25.e46

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자료유형: 학술저널

저자정보: 이효재 (Department of Radiology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.) 강승완 (Department of Radiology Chonnam National University Hospital Chonnam National University Medical Sc) 이종은 (Department of Radiology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.) 정원기 (Department of Radiology Chonnam National University Hwasun Hospital Hwasun Korea.) 이지신 (Department of Pathology Chonnam National University Hwasun Hospital Chonnam National University Med) 박민호 (Department of Surgery, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Korea) 임효순 (Department of Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Korea.)

저널정보: 한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.25 No.6

발행연도: 2022.12

수록면: 513 - 521 (9page)

DOI: 10.4048/jbc.2022.25.e46

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The apocrine morphology of the breast is observed in a broad pathological spectrum, ranging from benign cysts to invasive carcinomas. However, the number of clinical research investigating malignant apocrine lesions is limited. This study retrospectively reviewed the data of patients with malignant apocrine lesions admitted in a tertiary center between January 2004 and December 2021, based on the radiology-pathology correlation and the recent advances in their status to enhance the therapeutic implications of androgen receptor (AR). Among the 37 patients with lesions, 27 (73.0%) had triple-negative subtypes with predominant AR expression. The radiological features of malignant apocrine lesions did not differ from those of typical invasive ductal carcinoma or ductal carcinoma in situ. This study demonstrated that knowledge on the imaging features of malignant apocrine lesions and their histological basis could enhance the adoption of new targeted therapies in patients with this particular type of breast cancer.

#Apocrine Glands #Breast #Carcinoma #Receptors #Androgen

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이효재

소속기관 Department of Radiology Chonnam National University Hwasun Hospital Chonnam National University Medical School Hwasun Korea.