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논문 기본 정보

자료유형
학술저널
저자정보
Kim Sunpil (KU-KIST Graduate School of Converging Science and Technology Korea University) 김정연 (Emotion Cognition and Behavior Research Group Korea Brain Research Institute (KBRI) Daegu) Park Yongmin Mason (Center for Cognition and Sociality Institute for Basic Science (IBS)) Suh Pann-Ghill (Korea Brain Research Institute (KBRI) Daegu) 이창준 (KU-KIST Graduate School of Converging Science and Technology Korea University Seoul 02841 KoreaCent)
저널정보
한국뇌신경과학회 Experimental Neurobiology Experimental Neurobiology Vol.31 No.5
발행연도
2022.10
수록면
332 - 342 (11page)
DOI
10.5607/en22033

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Visuosocial memory is defined as stored visual information containing social context. Primates have a powerful ability to associate visuosocial memory with episodic memory. However, the existence of visuosocial memory in mice remains unclear. Here, we design a novel vision-specific social memory test using a portrait picture or mirrored self-image and demonstrate that mice can distinguish conspecific from other species by forming a visuosocial memory. Because CA2 hippocampus has been reported as a critical brain region for social memory, we develop CA2-specific blockade of memory formation through deletion of phospholipase C gamma 1 (PLCγ1), which is a key molecule in the brain-derived neurotrophic factor (BDNF) signaling pathway. Interestingly, these mice have intact sociability but impaired social memory in three chamber test and five-trial social memory test, which is highly dependent on visual information. Finally, PLCγ1 deletion in CA2 impairs visuosocial preference memory, but not avoidance memory, whereas non-social object recognition is intact. Our study proposes that mice have visuosocial memory, just as primates and humans.

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