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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.1
- 수록면
- 65 - 70 (6page)
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Background and Purpose Zolpidem is one of the most common hypnotics prescribed to treat insomnia worldwide. However, there are numerous reports of a positive association be tween zolpidem and mortality, including an association with increased cancer-specific mor tality found in a Taiwanese cohort study. This study aimed to determine the association be tween zolpidem use and brain-cancer-specific mortality in patients with brain cancer.
Methods This population-based, retrospective cohort study analyzed data in the National Health Insurance Service database. All incident cases of brain cancer at an age of ≥18 years at the time of brain cancer diagnosis over a 15-year period (2003?2017) were included. A mul tivariate Cox regression analysis after adjustment for covariables was performed to evaluate the associations of zolpidem exposure with brain-cancer-specific and all-cause mortality.
Results This study identified 38,037 incident cases of brain cancer, among whom 11,823 (31.1%) patients were exposed to zolpidem. In the multivariate Cox regression model, the brain-cancer-specific mortality rate was significantly higher in patients who were prescribed zolpidem than in those with no zolpidem prescription (adjusted hazard ratio [HR]=1.14, 95% confidence interval [CI]=1.08?1.21, p<0.001). Zolpidem exposure was significantly associat ed with increased brain-cancer-specific mortality after adjustment in younger adults (age 18? 64 years; adjusted HR=1.37, 95% CI=1.27?1.49) but not in older adults (age ≥65 years; adjust ed HR=0.94, 95% CI=0.86?1.02).
Conclusions Zolpidem exposure was significantly associated with increased brain-cancer specific mortality in patients with brain cancer aged 18?64 years. Further prospective studies are warranted to understand the mechanism underlying the effect of zolpidem on mortality in patients with brain cancer.
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