지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.8
- 수록면
- 318 - 325 (8page)
- DOI
- 10.3341/kjo.2022.0012
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초록· 키워드
오류제보하기
Purpose: Although there is still no consensus on the best animal model for dry eye disease research, a model based on lacrimalgland extraction (LGE) model is widely used. In this study, we aimed to investigate the histopathological changes takingplace on the contralateral eye after unilateral LGE to determine whether it is useful as a control.Methods: Seven-week-old male C57BL/6 mice were divided into naive control, environmental chamber model, and LGEgroups. Corneal fluorescein staining was scored to quantify the severity of damage. Morphological changes in the cornea,conjunctiva, and lacrimal gland (LG) were determined by hematoxylin and eosin staining and compared to those on naive controlanimals.Results: Compared to naive subjects, the unilateral LGE model showed enhanced corneal erosion scores and loss of conjunctivalgoblet cells, not only on the ipsilateral but also on the contralateral side. These changes in the ocular surface becamemore pronounced in a time-dependent manner. Furthermore, loss of LG acinar cells and leukocyte infiltration were detectedin the contralateral LGs of the LGE model.Conclusions: Considering the changes observed in the ocular surface and LGs, the contralateral side of the LGE model maynot offer proper control conditions for the experimental comparison of the effects of dry eye disease in vivo. There may beregulatory feedback or crosstalk system between both eyes activated in response to LGE.
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