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논문 기본 정보

자료유형
학술저널
저자정보
Sung Wook Kim (Department of Korean Medicine College of Korean Medicine Woosuk University Jeonju Republic of Korea) Jun Ho Lee (Department of Korean Medicine College of Korean Medicine Woosuk University Jeonju Republic of Korea) Hyeonjin Kim (Department of Korean Medicine College of Korean Medicine Woosuk University Jeonju Republic of Korea) Seong Hoon Lee (Department of Korean Medicine College of Korean Medicine Woosuk University Jeonju Republic of Korea) Dajeong Jeong (Department of Korean Medicine College of Korean Medicine Woosuk University Jeonju Republic of Korea) Hyuk Soon Kim (Department of Biomedical Sciences College of Natural Science and Department of Health Sciences The) Cheol-Jung Lee (Research Center for Materials Analysis Korea Basic Science Institute Daejeon Republic of Korea) Dae Yong Kim (Department of Korean Medicine College of Korean Medicine Woosuk University Jeonju Republic of Korea) Tae-han Yook (Department of Korean Medicine College of Korean Medicine Woosuk University) Gabsik Yang (Department of Korean Medicine College of Korean Medicine Woosuk University Jeonju Republic of Korea)
저널정보
대한약침학회 Journal of Pharmacopuncture Journal of Pharmacopuncture 제25권 제4호
발행연도
2022.12
수록면
396 - 403 (8page)
DOI
doi.org/10.3831/KPI.2022.25.4.396

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Objectives: Gout is an inflammatory arthritis of the joints and soft tissues occurring due to deposition of monosodium urate (MSU) crystals, which are caused by persistent hyperuricemia. Soyeom pharmacopuncture is one treatment method that has been traditionally used for pain management in Oriental medicine. However, studies on its effect in reducing gout pain have been insufficient. Therefore, we selected Soyeom pharmacopuncture among natural products used in Korea as the new target of our study. Methods: The effects of Soyeom pharmacopuncture were examined in mouse models of acute gout induced by injection of MSU crystals into footpads. IL-1β, IL-6, and TNF-α production were examined by immunoblotting and enzyme-linked immunosorbent assay as hallmarks of NLRP3 inflammasome and cytokine activation. Results: Soyeom pharmacopuncture reduced foot edema in gout-induced mice, as well as IL-1β, nitrite, IL-6, and TNF-α production. Moreover, Soyeom pharmacopuncture also reduced MSU-induced gout inflammatory gene expressions, specifically those in the NF-kB pathway. Conclusion: Pharmacopuncture may serve as a new solution for other inflammatory diseases as well. Through active follow-up studies, we could thoroughly understand the clinical value of Soyeom pharmacopuncture.

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