Therapeutic Potential of Active Components from Acorus gramineus and Acorus tatarinowii in Neurological Disorders and Their Application in Korean Medicine

Kim Cheol Ju; Kwak Tae Young; Bae Min Hyeok; Shin Hwa Kyoung; Choi Byung Tae

doi:10.3831/KPI.2022.25.4.326

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자료유형: 학술저널

저자정보: Kim Cheol Ju (Department of Korean Medicine School of Korean Medicine Pusan National University Yangsan Republic) Kwak Tae Young (Department of Korean Medicine School of Korean Medicine Pusan National University Yangsan Republic) Bae Min Hyeok (Department of Korean Medicine School of Korean Medicine Pusan National University Yangsan Republic) Shin Hwa Kyoung (Department of Korean Medicine School of Korean Medicine Pusan National University Yangsan Republic) Choi Byung Tae (Department of Korean Medicine School of Korean Medicine Pusan National University Yangsan Republic)

저널정보: 대한약침학회 Journal of Pharmacopuncture Journal of Pharmacopuncture 제25권 제4호

발행연도: 2022.12

수록면: 326 - 343 (18page)

DOI: 10.3831/KPI.2022.25.4.326

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Neurological disorders represent a substantial healthcare burden worldwide due to population aging. Acorus gramineus Solander (AG) and Acorus tatarinowii Schott (AT), whose major component is asarone, have been shown to be effective in neurological disorders. This review summarized current information from preclinical and clinical studies regarding the effects of extracts and active components of AG and AT (e.g., α-asarone and β-asarone) on neurological disorders and biomedical targets, as well as the mechanisms involved. Databases, including PubMed, Embase, and RISS, were searched using the following keywords: asarone, AG, AT, and neurological disorders, including Alzheimer’s disease, Parkinson’s disease, depression and anxiety, epilepsy, and stroke. Meta-analyses and reviews were excluded. A total of 873 studies were collected. A total of 89 studies were selected after eliminating studies that did not meet the inclusion criteria. Research on neurological disorders widely reported that extracts or active components of AG and AT showed therapeutic efficacy in treating neurological disorders. These components also possessed a wide array of neuroprotective effects, including reduction of pathogenic protein aggregates, antiapoptotic activity, modulation of autophagy, anti-inflammatory and antioxidant activities, regulation of neurotransmitters, activation of neurogenesis, and stimulation of neurotrophic factors. Most of the included studies were preclinical studies that used in vitro and in vivo models, and only a few clinical studies have been performed. Therefore, this review summarizes the current knowledge on AG and AT therapeutic effects as a basis for further clinical studies, and clinical trials are required before these findings can be applied to human neurological disorders.

#alzheimer's disease #asarone #depression #epilepsy #parkinson's diseases #stroke

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