지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.2
- 수록면
- 148 - 158 (11page)
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Background: Diabetic kidney disease (DKD) is associated with an elevated risk of fractures. However, little is known about the association between proteinuric or non-proteinuric DKD and the risk of hip fracture. Thus, we investigated the incidence of hip fractures among Korean adults with type 2 diabetes mellitus (T2DM) stratified by DKD phenotype.
Methods: In this retrospective cohort study using the Korean National Health Insurance Service database, patients with T2DM who received at least one general health checkup between 2009 and 2012 were followed until the date of hip fracture, death, or December 31, 2018. We classified the DKD phenotype by proteinuria and estimated glomerular filtration rate (eGFR), as follows: no DKD (PU?GFR?), proteinuric DKD with normal eGFR (PU+GFR?), non-proteinuric DKD with reduced eGFR (PU?GFR+), and proteinuric DKD with reduced eGFR (PU+GFR+) Results: The cumulative incidence of hip fractures was highest in the PU+GFR+ group, followed by the PU?GFR+ group and the PU+GFR? group. After adjustment for confounding factors, the hazard ratio (HR) for hip fracture was still highest in the PU+GFR+ group. However, the PU+GFR? group had a higher HR for hip fracture than the PU?GFR+ group (PU+GFR+: HR, 1.69; 95% confidence interval [CI], 1.57 to 1.81; PU+GFR?: HR, 1.37; 95% CI, 1.30 to 1.46; PU?GFR+: HR, 1.20; 95% CI, 1.16 to 1.24 using the PU?GFR? group as the reference category).
Conclusion: The present study demonstrated that DKD was significantly associated with a higher risk of hip fracture, with proteinuria as a major determinant.
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