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논문 기본 정보

자료유형
학술저널
저자정보
Lee Ji Young (Department of Pediatrics Severance Children’s Hospital Yonsei University College of Medicine Seoul) Baek Seung Hwan (Department of Pediatrics Severance Children’s Hospital Yonsei University College of Medicine Seoul) Ahn Jong Gyun (Department of Pediatrics Severance Children’s Hospital Yonsei University College of Medicine Seoul) Yoon Seo Hee (Department of Pediatrics Severance Children’s Hospital Yonsei University College of Medicine Seoul) Kim Moon Kyu (Department of Pediatrics Severance Children’s Hospital Yonsei University College of Medicine Seoul) Kim Soo Yeon (Department of Pediatrics Severance Children’s Hospital Yonsei University College of Medicine Seoul) Kim Kyung Won (Department of Pediatrics Severance Children’s Hospital Yonsei University College of Medicine Seoul) Sohn Myung Hyun (Department of Pediatrics Severance Children’s Hospital Yonsei University College of Medicine Seoul) Kang Ji-Man (Department of Pediatrics Severance Children’s Hospital Yonsei University College of Medicine Seoul)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.37 No.1
발행연도
2022.1
수록면
1 - 12 (12page)
DOI
10.3346/jkms.2022.37.e3

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Background: We aimed to examine the delay in antiviral initiation in rapid antigen test (RAT) false-negative children with influenza virus infection and to explore the clinical outcomes. We additionally conducted a medical cost-benefit analysis. Methods: This single-center, retrospective study included children (aged < 10 years) with influenza-like illness (ILI), hospitalized after presenting to the emergency department during three influenza seasons (2016–2019). RAT-false-negativity was defined as RAT-negative and polymerase chain reaction-positive cases. The turnaround time to antiviral treatment (TAT) was from the time when RAT was prescribed to the time when the antiviral was administered. The medical cost analysis by scenarios was also performed. Results: A total of 1,430 patients were included, 7.5% were RAT-positive (n = 107) and 2.4% were RAT-false-negative (n = 20). The median TAT of RAT-false-negative patients was 52.8 hours, significantly longer than that of 4 hours in RAT-positive patients (19.2–100.1, P < 0.001). In the multivariable analysis, TAT of ≥ 24 hours was associated with a risk of severe influenza infection and the need for mechanical ventilation (odds ratio [OR], 6.8, P = 0.009 and OR, 16.2, P = 0.033, respectively). The medical cost varied from $11.7–187.3/ILI patient. Conclusion: Antiviral initiation was delayed in RAT-false-negative patients. Our findings support the guideline that children with influenza, suspected of having severe or progressive infection, should be treated immediately.
#Point-of-Care Testing #Polymerase Chain Reaction #Emergency Department #Oseltamivir #Republic of Korea

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