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자료유형
학술저널
저자정보
Kim Myungsook (Department of Laboratory Medicine and Research Institute of Bacterial Resistance Yonsei University) Yun Shin Young (Department of Laboratory Medicine and Research Institute of Bacterial Resistance Yonsei University) Lee Yunhee (Department of Laboratory Medicine and Research Institute of Bacterial Resistance Yonsei University) Lee Hyukmin (Department of Laboratory Medicine and Research Institute of Bacterial Resistance Yonsei University) Yong Dongeun (Department of Laboratory Medicine and Research Institute of Bacterial Resistance Yonsei University) Lee Kyungwon (Department of Laboratory Medicine and Research Institute of Bacterial Resistance Yonsei University)
저널정보
대한진단검사의학회 Annals of Laboratory Medicine Annals of Laboratory Medicine 제42권 제2호
발행연도
2022.3
수록면
188 - 195 (8page)
DOI
10.3343/alm.2022.42.2.188

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Background: Fusobacterium species are obligately anaerobic, gram-negative bacilli. Especially, F. nucleatum and F. necrophorum are highly relevant human pathogens. We investigated clinical differences in patients infected with Fusobacterium spp. and determined the antimicrobial susceptibility of Fusobacterium isolates. Methods: We collected clinical data of 86 patients from whom Fusobacterium spp. were isolated from clinical specimens at a tertiary-care hospital in Korea between 2003 and 2020. In total, 76 non-duplicated Fusobacterium isolates were selected for antimicrobial susceptibility testing by the agar dilution method, according to the Clinical and Laboratory Standards Institute guidelines (M11-A9). Results: F. nucleatum was most frequently isolated from blood cultures and was associated with hematologic malignancy, whereas F. necrophorum was mostly prevalent in head and neck infections. Anti-anaerobic agents were more commonly used to treat F. nucleatum and F. varium infections than to treat F. necrophorum infections. We observed no significant difference in mortality between patients infected with these species. All F. nucleatum and F. necrophorum isolates were susceptible to the antimicrobial agents tested. F. varium was resistant to clindamycin (48%) and moxifloxacin (24%), and F. mortiferum was resistant to penicillin G (22%) and ceftriaxone (67%). β-Lactamase activity was not detected. Conclusions: Despite the clinical differences among patients with clinically important Fusobacterium infections, there was no significant difference in the mortality rates. Some Fusobacterium spp. were resistant to penicillin G, ceftriaxone, clindamycin, or moxifloxacin. This study may provide clinically relevant data for implementing empirical treatment against Fusobacterium infections.

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