Machine Learning-Based Predictor for Treatment Outcomes of Patients With Salivary Gland Cancer After Operation

정민철; 고윤우; 최은창; 임재열; 김세헌; 박영민

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자료유형: 학술저널

저자정보: 정민철 (연세대학교 의과대학 이비인후과학교실) 고윤우 (연세대학교) 최은창 (연세대학교) 임재열 (연세대학교 의과대학 이비인후과학교실) 김세헌 (연세대학교) 박영민 (연세대학교)

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후-두경부외과학회지 제65권 제6호

발행연도: 2022.6

수록면: 334 - 342 (9page)

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Background and Objectives The purpose of this study was to analyze the survival data of salivary gland cancer (SGCs) patients to construct machine learning and deep learning mod- els that can predict survival and use them to stratify SGC patients according to risk estimate. Subjects and Method We retrospectively analyzed the clinicopathologic data from 460 pa- tients with SGCs from 2006 to 2018. Results In Cox proportional hazard (CPH) model, pM, stage, lymphovascular invasion, lymph node ratio, and age exhibited significant correlation with patient’s survival. In the CPH model, the c-index value for the training set was 0.85, and that for the test set was 0.81. In the Random Survival Forest model, the c-index value for the training set was 0.86, and that for the test set was 0.82. Stage and age exhibited high importance in both the Random Survival For- est and CPH models. In the deep learning-based model, the c-index value was 0.72 for the training set and 0.72 for the test set. Among the three models mentioned above, the Random Survival Forest model exhibited the highest performance in predicting the survival of SGC patients. Conclusion A survival prediction model using machine learning techniques showed accept- able performance in predicting the survival of SGC patients. Although large-scale clinical and multicenter studies should be conducted to establish more powerful predictive model, we ex- pect that individualized treatment can be realized according to risk stratification made by the machine learning model.

#Deep learning #Machine learning #Prognosis #Salivary gland cancer.

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