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논문 기본 정보

자료유형
학술저널
저자정보
Mikhail I. Kogan (Rostov State Medical University) Khalid S. Ibishev (Rostov State Medical University) Yulia L. Naboka (Rostov State Medical University) Irina A. Gudima (Rostov State Medical University) Akhmed Kh. Ferzauli (Regional Clinical Hospital No. 2) Ruslan S. Ismailov (Rostov State Medical University) Kurt G. Naber (Technical University of Munich)
저널정보
대한비뇨기과학회 Investigative and Clinical Urology Investigative and Clinical Urology Vol.63 No.3
발행연도
2022.5
수록면
325 - 333 (9page)
DOI
https://doi.org/10.4111/icu.20210451

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Purpose: Because of the insufficient efficacy of the current treatment of chronic bacterial prostatitis (CBP), it is justified to search for a more effective antibiotic therapy (ABT). Materials and Methods: This single-centre prospective observational comparative study was conducted in 2012 to 2019 (patients: 60 men with CBP; age: 20?45 y). The clinical examination was performed on admission and at 1, 3, 6, or 12 months. All patients underwent the Meares?Stamey test to obtain expressed prostatic secretion (EPS) and/or post-massage urine (PMU) samples for extended bacteriological examination. The patients were randomly divided into 2 treatment groups (30/30 patients): group I, fluoroquinolones (FQs); group II, a combination of FQs with cephalosporins/macrolides with a treatment duration of 1 month. Results: Patients of both groups had severe symptomatic CBP with an average duration of 4 years. Twenty-three microorganisms (15 aerobes, 9 anaerobes) were identified in PMU. At 3 months follow-up, a positive clinical effect was noted in both groups, which was significant (p<0.05) only in group II concerning NIH-CPSI questionnaire, leukocyturia, prostate volume, maximum urine flow, and decreased pathospermia. At 6 months follow-up, in group II the frequency of Escherichia coli and Enterococcus spp. decreased significantly. In group I aerobes changed only insignificantly from the initial level, but anaerobes increased significantly. In group II the titers of both, aerobes and anaerobes, were significantly lower (p<0.05) at 6 months follow-up as compared to initial values. Conclusions: ABT targeting all taxa in EPS/PMU is a more effective alternative to standard therapeutic regimens for CBP.

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