지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Schwann cell is a unique neuroglial cell and has essential functions for regulating Wallerian degeneration and peripheral nerve regeneration after nerve injury. When Wallerian degeneration is inefficient or irreversible due to non-function or malfunction of Schwann cells, peripheral nerve regeneration doesn’t occur and peripheral neurodegenerative diseases are induced, such as diabetic neuropathies. However, effective medicinal therapeutics has not been developed. In this study, we employed a synthesized chiral 1,4-oxazpan-3-one (1,4-DZ) compound to investigate neuroanatomically degenerative characteristics of Schwann cells during Wallerian degeneration. We also used ex vivo sciatic nerve explant system to exclude macrophage effects on demyelination, performed immunostaining by using teased nerve fiber samples to observe the outlook of myelin sheath during Wallerian degeneration, and identified its inhibitory effects on the degeneration. Thus, our results suggested that 1,4-DZ could be a prototype to develop a new small drug for peripheral neurodegenerative diseases.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2023-511-000336896