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논문 기본 정보

자료유형
학술저널
저자정보
Kiseok Kim (Soonchunhyang University Cheonan Hospital) Yong-Jin Lee (Soonchunhyang University Cheonan Hospital) Soon-Chan Kwon (Soonchunhyang University Cheonan Hospital) Young-Sun Min (Soonchunhyang University Cheonan Hospital) Hyun Kyo Lee (Soonchunhyang University Cheonan Hospital) Gwangin Baek (Soonchunhyang University Cheonan Hospital) Sang Hyeon Kim (Soonchunhyang University Cheonan Hospital) Eun-Chul Jang (Soonchunhyang University Cheonan Hospital)
저널정보
대한직업환경의학회 대한직업환경의학회지 대한직업환경의학회지 제34권 제6호
발행연도
2022.11
수록면
91 - 103 (13page)

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Background: Circadian rhythm disturbance caused by shift work has adverse effects on the metabolic homeostasis of the liver. Disruption of the metabolic homeostasis of the liver causes fat accumulation in the liver. The aim of this study was to investigate the correlation between shift work and non-alcoholic fatty liver disease (NAFLD) among male workers in the steel manufacturing industry of Korea.
Methods: Based on medical examination data collected in June 2020, 2,511 male subjects from one steel manufacturing company in Korea were selected in total. NAFLD was evaluated using abdominal ultrasound, which was performed by two experienced radiologists. The multinomial logistic regression analysis was performed by adjusting for age, physical activity, smoking history, alcohol consumption, body mass index, waist circumference, blood pressure, blood glucose, lipidemia, liver function test, employment duration, and hepatotoxic materials exposure status.
Results: Compared to daytime workers, the odds ratio (OR) of moderate-severe NAFLD in shift workers was 1.449 (95% confidence interval [CI], 1.028–2.043). Compared to daytime workers, the ORs of moderate-severe NAFLD were significantly higher for the group that engaged in total shift work for more than 20 years (OR, 2.285; 95% CI, 1.051–4.970), the group that was not allowed to sleep during night shift work (OR, 1.463; 95% CI, 1.030–2.078), and the group that consumed food during night shift work (OR, 1.580; 95% CI, 1.093–2.284).
Conclusions: There was a correlation between shift work and moderate-severe NAFLD in male steel manufacturing workers. There will be a need for more research related to the correlation of shift work with steatohepatitis and cirrhosis in the future.

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ABSTRACT
BACKGROUND
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