지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.2
- 수록면
- 57 - 62 (6page)
이용수
초록· 키워드
오류제보하기
The selection of anesthetic agent is important in preclinical studies, since each agent affects the systemic hemodynamics in different ways. For that reason, we hypothesized that different anesthetic agents will result in different vaginal hemodynamic response and temperature during sexual arousal, in an animal model. To validate the hypothesis, animal experiments were performed using female rats with two anesthetic agents widely used in preclinical studies: ketamine and isoflurane. Our previously developed near-infrared-spectroscopy-based probe was used to measure the changes of oxyhemoglobin (OHb), deoxyhemoglobin (RHb), and total hemoglobin (THb) concentrations along with temperature from the animal vaginal wall. As a control, saline was administered to both isoflurane- and ketamine-anesthetized animals, and did not show any significant changes in OHb, RHb, THb, or temperature. However, an administration of apomorphine (APO, 80 μg/kg) induced increases of OHb (63 ± 28 μM/DPF), RHb (35 ± 20 μM/DPF), and THb (98 ± 49 μM/DPF) in ketamine-anesthetized animals, while decreases of OHb (52 ± 76 μM/DPF) and THb (38 ± 30 μM/DPF) and an increase of RHb (28 ± 51 μM/DPF) were found in isoflurane-anesthetized animals. The vaginal temperature decreased from the baseline in both ketamine-(0.42°C) and isoflurane- (1.22°C)anesthetized animals. These results confirmed our hypothesis, and suggest that a preclinical study monitoring hemodynamic responses under anesthesia should employ an appropriate anesthetic agent for the study.
목차
Ⅰ. INTRODUCTION
Ⅱ. MATERIALS AND METHODS
Ⅲ. RESULTS
Ⅳ. DISCUSSIONS AND CONCLUSION
REFERENCES
참고문헌 (27)
참고문헌 신청
L. J. Teppema / 2011 / Anesthetics and control of breathing / Respir. Physiol. Neurobiol 177:80~92
J. M. Cederholm / 2012 / Differential actions of isoflurane and ketamine-based anaesthetics on cochlear function in the mouse / Hear. Res 292:71~79
N. J. Michelson / 2018 / Isoflurane and ketamine differentially influence spontaneous and evoked laminar electrophysiology in mouse V1 / J. Neurophysiol 120:2232~2245
F. A. Guarraci / 2018 / The effects of ketamine on sexual behavior, anxiety, and locomotion in female rats / Pharmacol. Biochem. Behav 165:36~44
F. Giuliano / 2001 / Vaginal physiological changes in a model of sexual arousal in anesthetized rats / Am. J. Physiol. Regul. Integr. Comp. Physiol 281:R140~R149
J. M. Cederholm / 2012 / Differential actions of isoflurane and ketamine-based anaesthetics on cochlear function in the mouse / Hear. Res 292:71~79
N. J. Michelson / 2018 / Isoflurane and ketamine differentially influence spontaneous and evoked laminar electrophysiology in mouse V1 / J. Neurophysiol 120:2232~2245
F. A. Guarraci / 2018 / The effects of ketamine on sexual behavior, anxiety, and locomotion in female rats / Pharmacol. Biochem. Behav 165:36~44
F. Giuliano / 2001 / Vaginal physiological changes in a model of sexual arousal in anesthetized rats / Am. J. Physiol. Regul. Integr. Comp. Physiol 281:R140~R149
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